Srek1 MGI Mouse Gene Detail - MGI:2145245 - splicing regulatory glutamine/lysine-rich protein 1

Symbol

Srek1
Name

splicing regulatory glutamine/lysine-rich protein 1
Synonyms

AL118220, Sfrs12, SRrp508, SRrp86

Feature Type

protein coding gene
IDs

MGI:2145245
NCBI Gene: 218543
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:103875856-103911116 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 56.16 cM
Mapping Data

2 experiments

SNPs within 2kb

875 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145245	protein coding gene	Chr13:103873291-103911379 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020900	protein coding gene	Chr13:105825613-105849676 (-)
A/J	MGP_AJ_G0020851	protein coding gene	Chr13:101701279-101724114 (-)
AKR/J	MGP_AKRJ_G0020826	protein coding gene	Chr13:104792214-104815036 (-)
BALB/cJ	MGP_BALBcJ_G0020851	protein coding gene	Chr13:102404041-102436147 (-)
C3H/HeJ	MGP_C3HHeJ_G0020640	protein coding gene	Chr13:104538277-104561862 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021285	protein coding gene	Chr13:109003302-109028754 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018855	protein coding gene	Chr13:97323671-97345575 (-)
CAST/EiJ	MGP_CASTEiJ_G0020159	protein coding gene	Chr13:103992523-104018248 (-)
CBA/J	MGP_CBAJ_G0020602	protein coding gene	Chr13:113267817-113293571 (-)
DBA/2J	MGP_DBA2J_G0020726	protein coding gene	Chr13:101471252-101496464 (-)
FVB/NJ	MGP_FVBNJ_G0020708	protein coding gene	Chr13:100159253-100182106 (-)
LP/J	MGP_LPJ_G0020800	protein coding gene	Chr13:105845463-105868422 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020736	protein coding gene	Chr13:113415493-113438158 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021324	protein coding gene	Chr13:104277527-104302111 (-)
PWK/PhJ	MGP_PWKPhJ_G0019912	protein coding gene	Chr13:100206104-100228550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019734	protein coding gene	Chr13:100468008-100493015 (-)
WSB/EiJ	MGP_WSBEiJ_G0020217	protein coding gene	Chr13:104737276-104761009 (-)

Human Ortholog

SREK1, splicing regulatory glutamic acid and lysine rich protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SREK1, splicing regulatory glutamic acid and lysine rich protein 1
Synonyms

SFRS12, SRrp508, SRrp86
Links

HGNC:17882

NCBI Gene ID: 140890

neXtProt AC: NX_Q8WXA9

UniProt: Q8WXA9
Chr Location

5q12.3; chr5:66139971-66183615 (+) GRCh38

MGI Vertebrate Homology

Srek1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SREK1
Gene Tree

Srek1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srek1

ZFIN srek1

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All Sequences

86
RefSeq

29
UniProt

4
CCDS

CCDS26743.1, CCDS88513.1

Ensembl

ENSMUSG00000032621 (Evidence)
NCBI Gene

218543

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032621	Ensembl Gene Model \| MGI Sequence Detail	35261	C57BL/6J	± kb
transcript	ENSMUST00000074616	Ensembl \| MGI Sequence Detail	3934	Not Applicable
polypeptide	ENSMUSP00000074196	Ensembl \| MGI Sequence Detail	610	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014751 splicing factor, arginine/serine-rich 12

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034192 SREK1, RNA recognition motif 2
GlyGen

Q8BZX4 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 5

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MGI:2145251, MGI:3034554

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srek1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123885	Chr13:103911083-103911152 (-)	-2 bp
Tssr123884	Chr13:103910974-103911080 (-)	89 bp
Tssr123883	Chr13:103910432-103910434 (-)	683 bp
Tssr123882	Chr13:103904963-103904966 (-)	6,151 bp
Tssr123881	Chr13:103901010-103901013 (-)	10,104 bp
Tssr123880	Chr13:103894765-103894789 (-)	16,339 bp
Tssr123879	Chr13:103889632-103889656 (-)	21,472 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24