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Akr1c14 Gene Detail
Summary
  • Symbol
    Akr1c14
  • Name
    aldo-keto reductase family 1, member C14
  • Synonyms
    9030611N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145458
    NCBI Gene: 105387
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4099015-4140569 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    768 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145458
 protein coding gene Chr13:4099011-4140688 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020202
 protein coding gene Chr13:537285-568076 (+)
A/J MGP_AJ_G0020158
 protein coding gene Chr13:630250-661194 (+)
AKR/J MGP_AKRJ_G0020133
 protein coding gene Chr13:656258-687611 (+)
BALB/cJ MGP_BALBcJ_G0020141
 protein coding gene Chr13:634289-665158 (+)
C3H/HeJ MGP_C3HHeJ_G0019945
 protein coding gene Chr13:719092-749939 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020588
 protein coding gene Chr13:611556-643280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018200
 protein coding gene Chr13:539561-573150 (+)
CAST/EiJ MGP_CASTEiJ_G0019485
 protein coding gene Chr13:551751-584428 (+)
CBA/J MGP_CBAJ_G0019912
 protein coding gene Chr13:623302-655308 (+)
DBA/2J MGP_DBA2J_G0020029
 protein coding gene Chr13:552223-586689 (+)
FVB/NJ MGP_FVBNJ_G0020014
 protein coding gene Chr13:524560-556220 (+)
LP/J MGP_LPJ_G0020103
 protein coding gene Chr13:601914-634722 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020050
 protein coding gene Chr13:666310-702118 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020616
 protein coding gene Chr13:611067-643295 (+)
PWK/PhJ MGP_PWKPhJ_G0019247
 protein coding gene Chr13:611983-643452 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019052
 protein coding gene Chr13:655716-675954 (+)
WSB/EiJ MGP_WSBEiJ_G0019543
 protein coding gene Chr13:548303-590521 (+)



Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    neXtProt AC: NX_Q04828
    UniProt: Q04828

  • Chr Location
    10p15.1; chr10:4963253-4983283 (+)  GRCh38
  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1 member C2
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD-2, DD2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    neXtProt AC: NX_P52895
    UniProt: P52895

  • Chr Location
    10p15.1; chr10:4987775-5018031 (-)  GRCh38
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    neXtProt AC: NX_P42330
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5035354-5107686 (+)  GRCh38
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
  • Links
    NCBI Gene ID: 1109
    neXtProt AC: NX_P17516
    UniProt: P17516

  • Chr Location
    10p15.1; chr10:5195462-5218949 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human AKR1C2,AKR1C3,AKR1C4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the placenta exhibit sex-linked myelination alteration and autism-like behaviors in male mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    46
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    22
  • cDNA Data
    9
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 105387 NCBI Gene Model | MGI Sequence Detail 41555 C57BL/6J ±  kb
transcript NM_134072 RefSeq | MGI Sequence Detail 2445 C57BL/6  
polypeptide NP_598833 RefSeq | MGI Sequence Detail 323 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR020471 Aldo-keto reductase
    IPR018170 Aldo/keto reductase, conserved site
    IPR044482 Aldo-keto reductase family 1 member C
    IPR023210 NADP-dependent oxidoreductase domain
    IPR036812 NADP-dependent oxidoreductase domain superfamily
Molecular
Reagents
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  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:354375 Hardy DO, et al., Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. Endocrinology. 2000 May;141(5):1608-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory