Scrib MGI Mouse Gene Detail - MGI:2145950 - scribbled planar cell polarity

Symbol

Scrib
Name

scribbled planar cell polarity
Synonyms

Crc, mKIAA0147, Scrb1

Feature Type

protein coding gene
IDs

MGI:2145950
NCBI Gene: 105782
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:75919011-75941633 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.29 cM
Mapping Data

2 experiments

SNPs within 2kb

460 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145950	protein coding gene	Chr15:75919007-75941633 (-)
129S1/SvImJ	ENSMUSG00200049196	protein coding gene	Chr15:73036147-73059024 (-)
A/J	ENSMUSG00195047524	protein coding gene	Chr15:73010578-73033455 (-)
AKR/J	ENSMUSG00220048244	protein coding gene	Chr15:73021631-73044508 (-)
BALB/cJ	ENSMUSG00180049568	protein coding gene	Chr15:72837294-72860172 (-)
C3H/HeJ	ENSMUSG00175047876	protein coding gene	Chr15:73199176-73222053 (-)
C57BL/6NJ	ENSMUSG00215051264	protein coding gene	Chr15:72927974-72950851 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019909	protein coding gene	Chr15:70000483-70020327 (-)
CAST/EiJ	ENSTCUG00005038137	protein coding gene	Chr15:72545852-72568694 (-)
CBA/J	ENSMUSG00210046573	protein coding gene	Chr15:72974411-72997288 (-)
DBA/2J	ENSMUSG00185042999	protein coding gene	Chr15:72953132-72976009 (-)
FVB/NJ	ENSMUSG00205028090	protein coding gene	Chr15:72703849-72726726 (-)
JF1/MsJ	ENSUMUG00000055351	protein coding gene	Chr15:72611800-72634709 (-)
LP/J	ENSMUSG00230051528	protein coding gene	Chr15:76317101-76339978 (-)
NOD/ShiLtJ	ENSMUSG00190037740	protein coding gene	Chr15:72956822-72979697 (-)
NZO/HlLtJ	ENSMUSG00225049337	protein coding gene	Chr15:76621623-76644500 (-)
PWK/PhJ	ENSLUMG00010047916	protein coding gene	Chr15:72892930-72915822 (-)
SPRET/EiJ	ENSMSPG00010048323	protein coding gene	Chr15:74505178-74528026 (-)
WSB/EiJ	ENSIUOG00005043820	protein coding gene	Chr15:73013898-73036773 (-)

Human Ortholog

SCRIB, scribble planar cell polarity protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCRIB, scribble planar cell polarity protein
Synonyms

CRIB1, oSCRIB, SCRB1, SCRIB1, Vartul
Links

HGNC:30377

NCBI Gene ID: 23513

UniProt: C0HLS1, Q14160
Chr Location

8q24.3; chr8:143790920-143815773 (-) GRCh38

MGI Vertebrate Homology

Scrib stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCRIB
Gene Tree

Scrib

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Mutations/Alleles

2 with disease annotations

References

4 with disease annotations

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Phenotype Summary

64 phenotypes from 10 alleles in 14 genetic backgrounds
24 phenotypes from multigenic genotypes
5 images
83 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (ENU)

2
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

2
Spontaneous

2
Targeted

10
Genomic Mutations

5 involving Scrib
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display partial prenatal lethality. Mice homozygous for spontaneous or induced alleles exhibit craniofacial or neural tube defects.

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All GO Annotations

174
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

688
Tissues

52
cDNA Data

147
Literature Summary

60

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SCRIB

Xenbase scrib

ZFIN scrib

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All Sequences

82
RefSeq

26
UniProt

4
CCDS

CCDS27560.1, CCDS79381.1, CCDS79382.1

Ensembl

ENSMUSG00000022568 (Evidence)
NCBI Gene

105782

			Length	Strain/Species	Flank
genomic	105782	NCBI Gene Model \| MGI Sequence Detail	22623	C57BL/6J	± kb
transcript	NM_134089	RefSeq \| MGI Sequence Detail	5645	Not Specified
polypeptide	Q80U72	UniProt \| EBI \| MGI Sequence Detail	1665	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014537 protein LAP4

(term hierarchy)
InterPro Domains

IPR055414 Disease resistance R13L4/SHOC-2-like, LRR domain

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR050614 Synaptic Scaffolding LAP/MAGUK Families
GlyGen

Q80U72 6 sites, 1 O-linked glycan (1 site)

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All nucleic 154

cDNA 147

Primer pair 7

Antibodies 8

Microarray probesets 4

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MGI:1859564

Summaries

All 181

Developmental Gene Expression 60

Diseases 4

Gene Ontology 22

Phenotypes 83
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Scrib:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134907	Chr15:75943400-75943431 (-)	-1,783 bp
Tssr134906	Chr15:75942771-75942789 (-)	-1,147 bp
Tssr134905	Chr15:75941609-75941626 (-)	15 bp
Tssr134904	Chr15:75941530-75941608 (-)	64 bp
Tssr134903	Chr15:75941243-75941304 (-)	359 bp
Tssr134902	Chr15:75923765-75923791 (-)	17,855 bp
Tssr134901	Chr15:75922625-75922644 (-)	18,998 bp
Tssr134900	Chr15:75921062-75921109 (-)	20,547 bp
Tssr134899	Chr15:75920419-75920429 (-)	21,209 bp
Tssr134898	Chr15:75920336-75920347 (-)	21,291 bp
Tssr134897	Chr15:75919505-75919550 (-)	22,105 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24