Amigo2 MGI Mouse Gene Detail - MGI:2145995 - adhesion molecule with Ig like domain 2

Symbol

Amigo2
Name

adhesion molecule with Ig like domain 2

Feature Type

protein coding gene
IDs

MGI:2145995
NCBI Gene: 105827
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:97142006-97145168 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 52.91 cM
Mapping Data

2 experiments

SNPs within 2kb

106 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145995	protein coding gene	Chr15:97141955-97145168 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022274	protein coding gene	Chr15:98888508-98891755 (-)
A/J	MGP_AJ_G0022233	protein coding gene	Chr15:94985611-94988824 (-)
AKR/J	MGP_AKRJ_G0022208	protein coding gene	Chr15:97864200-97867414 (-)
BALB/cJ	MGP_BALBcJ_G0022239	protein coding gene	Chr15:95200885-95204098 (-)
C3H/HeJ	MGP_C3HHeJ_G0022009	protein coding gene	Chr15:97895352-97898565 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022684	protein coding gene	Chr15:102531601-102534814 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020210	protein coding gene	Chr15:90953789-90957009 (-)
CAST/EiJ	MGP_CASTEiJ_G0021531	protein coding gene	Chr15:98785642-98788856 (-)
CBA/J	MGP_CBAJ_G0021976	protein coding gene	Chr15:105973055-105976269 (-)
DBA/2J	MGP_DBA2J_G0022103	protein coding gene	Chr15:94429162-94432376 (-)
FVB/NJ	MGP_FVBNJ_G0022082	protein coding gene	Chr15:93423428-93426453 (-)
LP/J	MGP_LPJ_G0022174	protein coding gene	Chr15:98997993-99001200 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022102	protein coding gene	Chr15:110120386-110123599 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022699	protein coding gene	Chr15:97981465-97984680 (-)
PWK/PhJ	MGP_PWKPhJ_G0021272	protein coding gene	Chr15:94522268-94525431 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021106	protein coding gene	Chr15:97776819-97780040 (-)
WSB/EiJ	MGP_WSBEiJ_G0021580	protein coding gene	Chr15:98506766-98509984 (-)

Human Ortholog

AMIGO2, adhesion molecule with Ig like domain 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMIGO2, adhesion molecule with Ig like domain 2
Synonyms

ALI1, AMIGO-2, DEGA
Links

HGNC:24073

NCBI Gene ID: 347902

neXtProt AC: NX_Q86SJ2

UniProt: Q86SJ2
Chr Location

12q13.11; chr12:47075707-47079959 (-) GRCh38

MGI Vertebrate Homology

Amigo2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AMIGO2
Gene Tree

Amigo2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Amigo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice exhibit starburst amacrine cell and rod bipolar cell dendrite arbor expansion and enhanced direction selectivity of direction-selective ganglion cell responses to starburst amacrine cell signals.

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All GO Annotations

16
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

42
cDNA Data

9
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AMIGO2

Xenbase amigo2

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All Sequences

43
RefSeq

6
UniProt

2
CCDS

CCDS27780.1

Ensembl

ENSMUSG00000048218 (Evidence)
NCBI Gene

105827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048218	Ensembl Gene Model \| MGI Sequence Detail	3163	C57BL/6J	± kb
transcript	ENSMUST00000229890	Ensembl \| MGI Sequence Detail	2998	Not Applicable
polypeptide	ENSMUSP00000155019	Ensembl \| MGI Sequence Detail	519	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003992 amphoterin-induced protein 2

(term hierarchy)
InterPro Domains

IPR031283 Amphoterin-induced protein

IPR000483 Cysteine-rich flanking region, C-terminal

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q80ZD9 9 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 9

Primer pair 2

Other 2

Microarray probesets 3

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MGI:2146206

Summaries

All 60

Developmental Gene Expression 10

Diseases 1

Gene Ontology 6

Phenotypes 27
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:347599 Raja R, et al., Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development. Genesis. 2024 Apr;62(2):e23594

TSS for Amigo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136110	Chr15:97145187-97145196 (-)	-24 bp
Tssr136109	Chr15:97145123-97145138 (-)	37 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24