Dennd3 MGI Mouse Gene Detail - MGI:2146009

Symbol

Dennd3
Name

DENN domain containing 3
Synonyms

E030003N15Rik

Feature Type

protein coding gene
IDs

MGI:2146009
NCBI Gene: 105841
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:73384409-73444091 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.01 cM
Mapping Data

2 experiments

SNPs within 2kb

1991 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146009	protein coding gene	Chr15:73384333-73444091 (+)
129S1/SvImJ	ENSMUSG00200019011	protein coding gene	Chr15:70502618-70560636 (+)
A/J	ENSMUSG00195027430	protein coding gene	Chr15:70557248-70616932 (+)
AKR/J	ENSMUSG00220021656	protein coding gene	Chr15:70477816-70537500 (+)
BALB/cJ	ENSMUSG00180021077	protein coding gene	Chr15:70329705-70389399 (+)
C3H/HeJ	ENSMUSG00175005073	protein coding gene	Chr15:70686430-70746117 (+)
C57BL/6NJ	ENSMUSG00215005445	protein coding gene	Chr15:70386872-70446558 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019863	protein coding gene	Chr15:67063116-67123368 (+)
CAST/EiJ	ENSTCUG00005019183	protein coding gene	Chr15:69995698-70054814 (+)
CBA/J	ENSMUSG00210025139	protein coding gene	Chr15:70467070-70526752 (+)
DBA/2J	ENSMUSG00185024356	protein coding gene	Chr15:70414617-70474611 (+)
FVB/NJ	ENSMUSG00205009559	protein coding gene	Chr15:70150470-70210156 (+)
JF1/MsJ	ENSUMUG00000012746	protein coding gene	Chr15:70066338-70124363 (+)
LP/J	ENSMUSG00230052310	protein coding gene	Chr15:73776566-73836257 (+)
NOD/ShiLtJ	ENSMUSG00190004224	protein coding gene	Chr15:70528037-70588031 (+)
NZO/HlLtJ	ENSMUSG00225052149	protein coding gene	Chr15:74054847-74114838 (+)
PWK/PhJ	ENSLUMG00010010310	protein coding gene	Chr15:70348224-70406107 (+)
SPRET/EiJ	ENSMSPG00010003936	protein coding gene	Chr15:72023443-72082972 (+)
WSB/EiJ	ENSIUOG00005020074	protein coding gene	Chr15:70522705-70582624 (+)

Human Ortholog

DENND3, DENN domain containing 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND3, DENN domain containing 3
Links

HGNC:29134

NCBI Gene ID: 22898

UniProt: A2RUS2
Chr Location

8q24.3; chr8:141117278-141195808 (+) GRCh38

MGI Vertebrate Homology

Dennd3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DENND3
Gene Tree

Dennd3

less

References

1 with disease annotations

less

Phenotype Summary

30 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

3
Endonuclease-mediated

3
Radiation induced

2
Targeted

2
Genomic Mutations

5 involving Dennd3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available

less

All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

25

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dennd3

ZFIN dennd3a, dennd3b

less

All Sequences

50
RefSeq

6
UniProt

3
CCDS

CCDS37100.1

Ensembl

ENSMUSG00000036661 (Evidence)
NCBI Gene

105841

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036661	Ensembl Gene Model \| MGI Sequence Detail	59683	C57BL/6J	± kb
transcript	ENSMUST00000043414	Ensembl \| MGI Sequence Detail	5299	Not Applicable
polypeptide	ENSMUSP00000046774	Ensembl \| MGI Sequence Detail	1274	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030628 DENN domain-containing protein 3

(term hierarchy)
PDB

6B3Y
InterPro Domains

IPR001194 cDENN domain

IPR005112 dDENN domain

IPR057977 DENND3-like, TPR repeats

IPR051696 DENN Domain-Containing GEFs

IPR043153 DENN domain, C-terminal lobe

IPR037516 Tripartite DENN domain

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

less

All nucleic 25

cDNA 25

Microarray probesets 3

Summaries

All 56

Diseases 1

Gene Ontology 6

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Dennd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131530	Chr15:73384408-73384456 (+)	23 bp
Tssr131531	Chr15:73384463-73384489 (+)	67 bp
Tssr131532	Chr15:73384493-73384539 (+)	107 bp
Tssr131533	Chr15:73384542-73384554 (+)	139 bp
Tssr131534	Chr15:73390416-73390464 (+)	6,031 bp
Tssr131535	Chr15:73430240-73430244 (+)	45,833 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24