Card10 MGI Mouse Gene Detail - MGI:2146012 - caspase recruitment domain family, member 10

Symbol

Card10
Name

caspase recruitment domain family, member 10
Synonyms

Bimp1, CARMA3

Feature Type

protein coding gene
IDs

MGI:2146012
NCBI Gene: 105844
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:78659338-78687242 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

2 experiments

SNPs within 2kb

872 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146012	protein coding gene	Chr15:78659323-78687261 (-)
129S1/SvImJ	ENSMUSG00200051765	protein coding gene	Chr15:75772308-75800152 (-)
A/J	ENSMUSG00195051319	protein coding gene	Chr15:75714672-75742523 (-)
AKR/J	ENSMUSG00220046966	protein coding gene	Chr15:75758134-75785982 (-)
BALB/cJ	ENSMUSG00180048637	protein coding gene	Chr15:75591710-75619555 (-)
C3H/HeJ	ENSMUSG00175052702	protein coding gene	Chr15:75903016-75930862 (-)
C57BL/6NJ	ENSMUSG00215050327	protein coding gene	Chr15:75669620-75697526 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019992	protein coding gene	Chr15:72774985-72803323 (-)
CAST/EiJ	ENSTCUG00005045803	protein coding gene	Chr15:75217201-75244504 (-)
CBA/J	ENSMUSG00210036602	protein coding gene	Chr15:75678210-75706056 (-)
DBA/2J	ENSMUSG00185045895	protein coding gene	Chr15:75688049-75715893 (-)
FVB/NJ	ENSMUSG00205045774	protein coding gene	Chr15:75407848-75435693 (-)
JF1/MsJ	ENSUMUG00000043628	protein coding gene	Chr15:75264106-75291860 (-)
LP/J	ENSMUSG00230051701	protein coding gene	Chr15:79020763-79048606 (-)
NOD/ShiLtJ	ENSMUSG00190032823	protein coding gene	Chr15:75698105-75726014 (-)
NZO/HlLtJ	ENSMUSG00225052933	protein coding gene	Chr15:79348947-79376930 (-)
PWK/PhJ	ENSLUMG00010050985	protein coding gene	Chr15:75485264-75512657 (-)
SPRET/EiJ	ENSMSPG00010042517	protein coding gene	Chr15:77148386-77175440 (-)
WSB/EiJ	ENSIUOG00005048159	protein coding gene	Chr15:75753151-75781061 (-)

Human Ortholog

CARD10, caspase recruitment domain family member 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARD10, caspase recruitment domain family member 10
Synonyms

BIMP1, CARMA3, IMD89
Links

HGNC:16422

NCBI Gene ID: 29775

UniProt: Q9BWT7
Chr Location

22q13.1; chr22:37490362-37519542 (-) GRCh38

MGI Vertebrate Homology

Card10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARD10
Gene Tree

Card10

Diseases

1 with human CARD10 associations

				Human Disease	Mouse Models
				immunodeficiency 89 IDs immunodeficiency 89 DOID:0061059 OMIM:619632

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Card10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

Mice homozygous for a null allele exhibit partial penetrance of anencephaly and subsequent perinatal lethality of anencephalic embryos.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

646
Tissues

10
cDNA Data

24
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

41
RefSeq

6
UniProt

2
CCDS

CCDS27623.2

Ensembl

ENSMUSG00000033170 (Evidence)
NCBI Gene

105844

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033170	Ensembl Gene Model \| MGI Sequence Detail	27905	C57BL/6J	± kb
transcript	ENSMUST00000164826	Ensembl \| MGI Sequence Detail	4726	Not Applicable
polypeptide	ENSMUSP00000129513	Ensembl \| MGI Sequence Detail	1070	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005033 caspase recruitment domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR042140 CARD10, CARD domain

IPR001315 CARD domain

IPR011029 Death-like domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 24

cDNA 24

Microarray probesets 3

Summaries

All 64

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Card10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135287	Chr15:78687215-78687250 (-)	9 bp
Tssr135286	Chr15:78687085-78687120 (-)	139 bp
Tssr135285	Chr15:78687070-78687084 (-)	165 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24