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Adamts12 Gene Detail
Summary
  • Symbol
    Adamts12
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146046
    NCBI Gene: 239337
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:11064876-11349317 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8939 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146046
 protein coding gene Chr15:11064781-11349321 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021730
 protein coding gene Chr15:8238385-8524390 (+)
A/J MGP_AJ_G0021690
 protein coding gene Chr15:7991965-8265770 (+)
AKR/J MGP_AKRJ_G0021668
 protein coding gene Chr15:8183913-8476460 (+)
BALB/cJ MGP_BALBcJ_G0021697
 protein coding gene Chr15:7889527-8174508 (+)
C3H/HeJ MGP_C3HHeJ_G0021473
 protein coding gene Chr15:8138406-8433041 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022136
 protein coding gene Chr15:8543143-8846237 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019673
 protein coding gene Chr15:7458420-7737658 (+)
CAST/EiJ MGP_CASTEiJ_G0020989
 protein coding gene Chr15:8201622-8506642 (+)
CBA/J MGP_CBAJ_G0021442
 protein coding gene Chr15:8746008-9075013 (+)
DBA/2J MGP_DBA2J_G0021566
 protein coding gene Chr15:7852179-8139431 (+)
FVB/NJ MGP_FVBNJ_G0021544
 protein coding gene Chr15:7712844-7994065 (+)
LP/J MGP_LPJ_G0021634
 protein coding gene Chr15:8140808-8440676 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021569
 protein coding gene Chr15:9001678-9310750 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022159
 protein coding gene Chr15:8167386-8470926 (+)
PWK/PhJ MGP_PWKPhJ_G0020732
 protein coding gene Chr15:8025773-8315562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020570
 protein coding gene Chr15:8112808-8414324 (+)
WSB/EiJ MGP_WSBEiJ_G0021045
 protein coding gene Chr15:8159688-8462976 (+)



Homology
more
  • Human Ortholog
    ADAMTS12, ADAM metallopeptidase with thrombospondin type 1 motif 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS12, ADAM metallopeptidase with thrombospondin type 1 motif 12
  • Synonyms
    PRO4389
  • Links
    NCBI Gene ID: 81792
    neXtProt AC: NX_P58397
    UniProt: P58397

  • Chr Location
    5p13.3-p13.2; chr5:33523535-33892019 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased tumor vascularization, tumor invasion, and angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    19
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047497 Ensembl Gene Model | MGI Sequence Detail 284442 C57BL/6J ±  kb
    transcript ENSMUST00000061318 Ensembl | MGI Sequence Detail 8579 Not Applicable  
    polypeptide ENSMUSP00000057796 Ensembl | MGI Sequence Detail 1600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory