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Agxt2 Gene Detail
Summary
  • Symbol
    Agxt2
  • Name
    alanine-glyoxylate aminotransferase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146052
    NCBI Gene: 268782
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:10358618-10410239 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1373 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146052
 protein coding gene Chr15:10358602-10410244 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021720
 protein coding gene Chr15:7479942-7538319 (+)
A/J MGP_AJ_G0021680
 protein coding gene Chr15:7297311-7343258 (+)
AKR/J MGP_AKRJ_G0021658
 protein coding gene Chr15:7460741-7509879 (+)
BALB/cJ MGP_BALBcJ_G0021687
 protein coding gene Chr15:7207697-7259091 (+)
C3H/HeJ MGP_C3HHeJ_G0021463
 protein coding gene Chr15:7402525-7458149 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022126
 protein coding gene Chr15:7773654-7829577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019663
 protein coding gene Chr15:6770912-6818217 (+)
CAST/EiJ MGP_CASTEiJ_G0020979
 protein coding gene Chr15:7465915-7516436 (+)
CBA/J MGP_CBAJ_G0021432
 protein coding gene Chr15:7944026-8004287 (+)
DBA/2J MGP_DBA2J_G0021556
 protein coding gene Chr15:7158474-7213536 (+)
FVB/NJ MGP_FVBNJ_G0021534
 protein coding gene Chr15:7026185-7075064 (+)
LP/J MGP_LPJ_G0021624
 protein coding gene Chr15:7386974-7439837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021559
 protein coding gene Chr15:8239187-8297964 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022149
 protein coding gene Chr15:7419343-7472253 (+)
PWK/PhJ MGP_PWKPhJ_G0020722
 protein coding gene Chr15:7318327-7369133 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020560
 protein coding gene Chr15:7384355-7433062 (+)
WSB/EiJ MGP_WSBEiJ_G0021035
 protein coding gene Chr15:7435870-7488515 (+)



Homology
more
  • Human Ortholog
    AGXT2, alanine--glyoxylate aminotransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGXT2, alanine--glyoxylate aminotransferase 2
  • Synonyms
    AGT2, BAIBA, DAIBAT
  • Links
    NCBI Gene ID: 64902
    neXtProt AC: NX_Q9BYV1
    UniProt: Q9BYV1

  • Chr Location
    5p13.2; chr5:34998101-35048135 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human AGXT2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit reduced circulating L-citrulline, hypertension under terminal aesthesia and increased vasodilation maximal response following acetylcholine treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    96
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000089678 Ensembl Gene Model | MGI Sequence Detail 51622 C57BL/6J ±  kb
    transcript ENSMUST00000022858 Ensembl | MGI Sequence Detail 1825 Not Applicable  
    polypeptide ENSMUSP00000022858 Ensembl | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000003850 alanine--glyoxylate aminotransferase 2, mitochondrial
      (term hierarchy)
    • EC
      2.6.1.18, 2.6.1.40, 2.6.1.44
    • InterPro Domains
      IPR005814 Aminotransferase class-III
      IPR049704 Aminotransferases class-III pyridoxal-phosphate attachment site
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      Q3UEG6 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145968
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory