Deptor MGI Mouse Gene Detail - MGI:2146322 - DEP domain containing MTOR-interacting protein

Symbol

Deptor
Name

DEP domain containing MTOR-interacting protein
Synonyms

4731402B04Rik, 9130412E02Rik, D15Ertd336e, D15Ertd597e, Depdc6

Feature Type

protein coding gene
IDs

MGI:2146322
NCBI Gene: 97998
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:54975824-55122667 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 21.96 cM
Mapping Data

4 experiments

SNPs within 2kb

5095 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146322	protein coding gene	Chr15:54975713-55122667 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021854	protein coding gene	Chr15:54185248-54334443 (+)
A/J	MGP_AJ_G0021814	protein coding gene	Chr15:52035634-52187070 (+)
AKR/J	MGP_AKRJ_G0021795	protein coding gene	Chr15:53519517-53675075 (+)
BALB/cJ	MGP_BALBcJ_G0021821	protein coding gene	Chr15:52259371-52409009 (+)
C3H/HeJ	MGP_C3HHeJ_G0021595	protein coding gene	Chr15:53600035-53753117 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022260	protein coding gene	Chr15:56288259-56441317 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019797	protein coding gene	Chr15:49272323-49417309 (+)
CAST/EiJ	MGP_CASTEiJ_G0021112	protein coding gene	Chr15:54191366-54347920 (+)
CBA/J	MGP_CBAJ_G0021564	protein coding gene	Chr15:58268429-58431211 (+)
DBA/2J	MGP_DBA2J_G0021688	protein coding gene	Chr15:51930381-52078674 (+)
FVB/NJ	MGP_FVBNJ_G0021666	protein coding gene	Chr15:51051534-51202947 (+)
LP/J	MGP_LPJ_G0021758	protein coding gene	Chr15:53985345-54138244 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021690	protein coding gene	Chr15:63374283-63535317 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022283	protein coding gene	Chr15:53860115-54019521 (+)
PWK/PhJ	MGP_PWKPhJ_G0020857	protein coding gene	Chr15:52005918-52149607 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020694	protein coding gene	Chr15:53607598-53764082 (+)
WSB/EiJ	MGP_WSBEiJ_G0021167	protein coding gene	Chr15:53839616-53989902 (+)

Human Ortholog

DEPTOR, DEP domain containing MTOR interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DEPTOR, DEP domain containing MTOR interacting protein
Synonyms

DEP.6, DEPDC6, hDEPTOR
Links

HGNC:22953

NCBI Gene ID: 64798

neXtProt AC: NX_Q8TB45

UniProt: Q8TB45
Chr Location

8q24.12; chr8:119873717-120050918 (+) GRCh38

MGI Vertebrate Homology

Deptor stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DEPTOR
Gene Tree

Deptor

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

19
Radiation induced

1
Targeted

9
Genomic Mutations

4 involving Deptor
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous conditional KO in the liver results in lower hepatic glycogen content and increased oxidative metabolism in fasted mice.

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All GO Annotations

28
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

6
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase deptor, deptorl

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All Sequences

61
RefSeq

4
UniProt

5
CCDS

CCDS27474.1, CCDS27475.1

Ensembl

ENSMUSG00000022419 (Evidence)
NCBI Gene

97998

			Length	Strain/Species	Flank
genomic	97998	NCBI Gene Model \| MGI Sequence Detail	146844	C57BL/6J	± kb
transcript	NM_145470	RefSeq \| MGI Sequence Detail	8436	C57BL/6
polypeptide	Q570Y9	UniProt \| EBI \| MGI Sequence Detail	409	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029102 DEP domain-containing mTOR-interacting protein

(term hierarchy)
InterPro Domains

IPR000591 DEP domain

IPR037335 DEP domain-containing mTOR-interacting protein, DEP domain 1

IPR037336 DEP domain-containing mTOR-interacting protein, DEP domain 2

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR051832 Regulators of mTOR signaling and Rac activation

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q570Y9 1 site, 1 N-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 9

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MGI:1196436, MGI:1289169, MGI:1918827, MGI:1921823

Summaries

All 80

Developmental Gene Expression 4

Diseases 1

Gene Ontology 5

Phenotypes 39
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Deptor:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131287	Chr15:54975727-54975742 (+)	-89 bp
Tssr131288	Chr15:54975756-54975799 (+)	-46 bp
Tssr131289	Chr15:54975816-54975847 (+)	8 bp
Tssr131290	Chr15:54975848-54975880 (+)	40 bp
Tssr131291	Chr15:55072121-55072128 (+)	96,301 bp
Tssr131292	Chr15:55072163-55072179 (+)	96,347 bp
Tssr131293	Chr15:55115829-55115848 (+)	140,015 bp
Tssr131294	Chr15:55119172-55119183 (+)	143,354 bp
Tssr131295	Chr15:55121794-55121800 (+)	145,973 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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