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Vps8 Gene Detail
Summary
  • Symbol
    Vps8
  • Name
    VPS8 CORVET complex subunit
  • Synonyms
    mKIAA0804
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146407
    NCBI Gene: 209018
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21241868-21463430 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6776 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146407
 protein coding gene Chr16:21241859-21463431 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022659
 protein coding gene Chr16:18847750-19072649 (+)
A/J MGP_AJ_G0022621
 protein coding gene Chr16:17950107-18171444 (+)
AKR/J MGP_AKRJ_G0022596
 protein coding gene Chr16:18699363-18931970 (+)
BALB/cJ MGP_BALBcJ_G0022625
 protein coding gene Chr16:18130203-18359339 (+)
C3H/HeJ MGP_C3HHeJ_G0022390
 protein coding gene Chr16:18806727-19031863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023076
 protein coding gene Chr16:19228101-19480212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020594
 protein coding gene Chr16:18654634-18867173 (+)
CAST/EiJ MGP_CASTEiJ_G0021920
 protein coding gene Chr16:18791457-19017851 (+)
CBA/J MGP_CBAJ_G0022362
 protein coding gene Chr16:20062033-20303724 (+)
DBA/2J MGP_DBA2J_G0022494
 protein coding gene Chr16:17938922-18157697 (+)
FVB/NJ MGP_FVBNJ_G0022469
 protein coding gene Chr16:17910858-18128285 (+)
LP/J MGP_LPJ_G0022561
 protein coding gene Chr16:18596290-18825476 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022489
 protein coding gene Chr16:19655271-19892737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023087
 protein coding gene Chr16:18639359-18876699 (+)
PWK/PhJ MGP_PWKPhJ_G0021660
 protein coding gene Chr16:18156173-18373437 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021490
 protein coding gene Chr16:18422126-18652213 (+)
WSB/EiJ MGP_WSBEiJ_G0021963
 protein coding gene Chr16:18606571-18841089 (+)



Homology
more
  • Human Ortholog
    VPS8, VPS8 subunit of CORVET complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS8, VPS8 subunit of CORVET complex
  • Synonyms
    KIAA0804
  • Links
    NCBI Gene ID: 23355
    neXtProt AC: NX_Q8N3P4
    UniProt: Q8N3P4

  • Chr Location
    3q27.2; chr3:184812143-185052614 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    6
  • cDNA Data
    65
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033653 Ensembl Gene Model | MGI Sequence Detail 221563 C57BL/6J ±  kb
transcript ENSMUST00000117598 Ensembl | MGI Sequence Detail 4935 Not Applicable  
polypeptide ENSMUSP00000112937 Ensembl | MGI Sequence Detail 1427 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000017348 vacuolar protein sorting-associated protein 8
    (term hierarchy)
  • InterPro Domains
    IPR025941 Vacuolar protein sorting-associated protein 8, central domain
    IPR045111 Vacuolar protein sorting-associated protein Vps41/Vps8
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146573
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:297661 Suto JI, et al., Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice. Congenit Anom (Kyoto). 2020 Dec 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory