Osbpl11 MGI Mouse Gene Detail - MGI:2146553 - oxysterol binding protein-like 11

Symbol

Osbpl11
Name

oxysterol binding protein-like 11
Synonyms

ORP-11

Feature Type

protein coding gene
IDs

MGI:2146553
NCBI Gene: 106326
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:33005441-33063682 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 23.71 cM
Mapping Data

2 experiments

SNPs within 2kb

1229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146553	protein coding gene	Chr16:33005441-33063682 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022753	protein coding gene	Chr16:31363600-31422906 (+)
A/J	MGP_AJ_G0022718	protein coding gene	Chr16:29868983-29927212 (+)
AKR/J	MGP_AKRJ_G0022691	protein coding gene	Chr16:30914049-30974149 (+)
BALB/cJ	MGP_BALBcJ_G0022720	protein coding gene	Chr16:29969300-30033141 (+)
C3H/HeJ	MGP_C3HHeJ_G0022485	protein coding gene	Chr16:31037882-31101706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023169	protein coding gene	Chr16:32060013-32123633 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020687	protein coding gene	Chr16:30204902-30264939 (+)
CAST/EiJ	MGP_CASTEiJ_G0022013	protein coding gene	Chr16:31188858-31252403 (+)
CBA/J	MGP_CBAJ_G0022455	protein coding gene	Chr16:33317881-33393729 (+)
DBA/2J	MGP_DBA2J_G0022588	protein coding gene	Chr16:29678657-29738626 (+)
FVB/NJ	MGP_FVBNJ_G0022563	protein coding gene	Chr16:29675281-29737677 (+)
LP/J	MGP_LPJ_G0022655	protein coding gene	Chr16:31106133-31168910 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022582	protein coding gene	Chr16:32737907-32807711 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023181	protein coding gene	Chr16:30909698-30973416 (+)
PWK/PhJ	MGP_PWKPhJ_G0021754	protein coding gene	Chr16:30057195-30116256 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021583	protein coding gene	Chr16:30724755-30784708 (+)
WSB/EiJ	MGP_WSBEiJ_G0022057	protein coding gene	Chr16:30881023-30944810 (+)

Human Ortholog

OSBPL11, oxysterol binding protein like 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OSBPL11, oxysterol binding protein like 11
Synonyms

ORP-11, ORP11, OSBP12, TCCCIA00292
Links

HGNC:16397

NCBI Gene ID: 114885

neXtProt AC: NX_Q9BXB4

UniProt: Q9BXB4
Chr Location

3q21.2; chr3:125528858-125595497 (-) GRCh38

MGI Vertebrate Homology

Osbpl11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OSBPL11
Gene Tree

Osbpl11

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

10
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

15
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase osbpl11

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All Sequences

43
RefSeq

2
UniProt

3
CCDS

CCDS28128.1

Ensembl

ENSMUSG00000022807 (Evidence)
NCBI Gene

106326

			Length	Strain/Species	Flank
genomic	106326	NCBI Gene Model \| MGI Sequence Detail	58242	C57BL/6J	± kb
transcript	NM_176840	RefSeq \| MGI Sequence Detail	4521	C57BL/6
polypeptide	Q8CI95	UniProt \| EBI \| MGI Sequence Detail	751	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012046 oxysterol-binding protein-related protein 11

(term hierarchy)
InterPro Domains

IPR000648 Oxysterol-binding protein

IPR018494 Oxysterol-binding protein, conserved site

IPR037239 Oxysterol-binding protein superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

Q8CI95 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 4

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MGI:2146378

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Osbpl11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138082	Chr16:33005415-33005523 (+)	28 bp
Tssr138083	Chr16:33005526-33005538 (+)	91 bp
Tssr138084	Chr16:33027395-33027399 (+)	21,956 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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