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Nsun3 Gene Detail
Summary
  • Symbol
    Nsun3
  • Name
    NOL1/NOP2/Sun domain family member 3
  • Synonyms
    6720484A09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146565
    NCBI Gene: 106338
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:62552807-62607181 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 36.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1733 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146565
 protein coding gene Chr16:62552807-62607238 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022934
 protein coding gene Chr16:62129686-62181072 (-)
A/J MGP_AJ_G0022902
 protein coding gene Chr16:59502821-59552534 (-)
AKR/J MGP_AKRJ_G0022872
 protein coding gene Chr16:61338622-61389925 (-)
BALB/cJ MGP_BALBcJ_G0022904
 protein coding gene Chr16:59697246-59752046 (-)
C3H/HeJ MGP_C3HHeJ_G0022666
 protein coding gene Chr16:61654705-61707551 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023352
 protein coding gene Chr16:63987608-64050979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020855
 protein coding gene Chr16:58670064-58717501 (-)
CAST/EiJ MGP_CASTEiJ_G0022190
 protein coding gene Chr16:61872530-61928537 (-)
CBA/J MGP_CBAJ_G0022637
 protein coding gene Chr16:66623997-66677994 (-)
DBA/2J MGP_DBA2J_G0022769
 protein coding gene Chr16:59267930-59319134 (-)
FVB/NJ MGP_FVBNJ_G0022743
 protein coding gene Chr16:58910995-58962453 (-)
LP/J MGP_LPJ_G0022838
 protein coding gene Chr16:61984657-62038880 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022762
 protein coding gene Chr16:67683082-67739912 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023368
 protein coding gene Chr16:61420352-61471006 (-)
PWK/PhJ MGP_PWKPhJ_G0021932
 protein coding gene Chr16:59448819-59503778 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021762
 protein coding gene Chr16:61158645-61226654 (-)
WSB/EiJ MGP_WSBEiJ_G0022236
 protein coding gene Chr16:61508253-61558688 (-)



Homology
more
  • Human Ortholog
    NSUN3, NOP2/Sun RNA methyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSUN3, NOP2/Sun RNA methyltransferase 3
  • Synonyms
    COXPD48, MST077, MSTP077
  • Links
    NCBI Gene ID: 63899
    neXtProt AC: NX_Q9H649
    UniProt: Q9H649

  • Chr Location
    3q11.2; chr3:94062980-94131832 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NSUN3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic lethality between E10.5 and E12.5 and embryos are small. Heart-specific knock-out mice exhibit mild heart enlargement and mild increase in heart contraction with age and cardiac mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    46
  • cDNA Data
    33
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050312 Ensembl Gene Model | MGI Sequence Detail 54375 C57BL/6J ±  kb
    transcript ENSMUST00000063089 Ensembl | MGI Sequence Detail 3813 Not Applicable  
    polypeptide ENSMUSP00000059720 Ensembl | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029653 tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR023267 RNA (C5-cytosine) methyltransferase
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR049560 SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
      IPR001678 SAM-dependent methyltransferase RsmB-F/NOP2-type domain
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1924371
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:336777 Murakami Y, et al., NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice. Commun Biol. 2023 Mar 22;6(1):307
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory