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Eaf2 Gene Detail
Summary
  • Symbol
    Eaf2
  • Name
    ELL associated factor 2
  • Synonyms
    Festa, FESTA-L, FESTA-S, Traits, U19
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146616
    NCBI Gene: 106389
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36613246-36695275 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1583 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146616
 protein coding gene Chr16:36613246-36695365 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022793
 protein coding gene Chr16:35201911-35296503 (-)
A/J MGP_AJ_G0022758
 protein coding gene Chr16:33473855-33555760 (-)
AKR/J MGP_AKRJ_G0022730
 protein coding gene Chr16:34756988-34839365 (-)
BALB/cJ MGP_BALBcJ_G0022759
 protein coding gene Chr16:33575834-33659349 (-)
C3H/HeJ MGP_C3HHeJ_G0022523
 protein coding gene Chr16:34868008-34956304 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023206
 protein coding gene Chr16:36050778-36139382 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020720
 protein coding gene Chr16:33838278-33921133 (-)
CAST/EiJ MGP_CASTEiJ_G0022049
 protein coding gene Chr16:34987888-35076970 (-)
CBA/J MGP_CBAJ_G0022494
 protein coding gene Chr16:37625159-37718726 (-)
DBA/2J MGP_DBA2J_G0022626
 protein coding gene Chr16:33366466-33451385 (-)
FVB/NJ MGP_FVBNJ_G0022601
 protein coding gene Chr16:33400803-33481595 (-)
LP/J MGP_LPJ_G0022694
 protein coding gene Chr16:34914891-35002607 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022620
 protein coding gene Chr16:36652167-36775278 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023221
 protein coding gene Chr16:34699600-34787600 (-)
PWK/PhJ MGP_PWKPhJ_G0021789
 protein coding gene Chr16:33767091-33851643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021620
 protein coding gene Chr16:34616856-34705443 (-)
WSB/EiJ MGP_WSBEiJ_G0022093
 protein coding gene Chr16:34755361-34844798 (-)



Homology
more
  • Human Ortholog
    EAF2, ELL associated factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EAF2, ELL associated factor 2
  • Synonyms
    BM040, TRAITS, U19
  • Links
    NCBI Gene ID: 55840
    neXtProt AC: NX_Q96CJ1
    UniProt: Q96CJ1

  • Chr Location
    3q13.33; chr3:121835183-121886526 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit premature death, enlarged heart and prostate associated with hypertrophy, increased tumor incidence, prostate inflammation and an increased prostatic intraepithelial neoplasia incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    159
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106389 NCBI Gene Model | MGI Sequence Detail 82030 C57BL/6J ±  kb
    transcript NM_134111 RefSeq | MGI Sequence Detail 1903 FVB/N  
    polypeptide Q91ZD6 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:85253 Saso K, et al., Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. J Biochem. 2003 Apr;133(4):493-500
    • Latest
      J:288972 Pascal LE, et al., Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice. Neoplasia. 2019 Aug;21(8):752-764
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory