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Plekhh2 Gene Detail
Summary
  • Symbol
    Plekhh2
  • Name
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146813
    NCBI Gene: 213556
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:84819323-84929566 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 55.02 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146813
 protein coding gene Chr17:84819303-84929571 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024079
 protein coding gene Chr17:87679623-87795779 (+)
A/J MGP_AJ_G0024038
 protein coding gene Chr17:84898619-85010249 (+)
AKR/J MGP_AKRJ_G0024007
 protein coding gene Chr17:86286068-86399942 (+)
BALB/cJ MGP_BALBcJ_G0024039
 protein coding gene Chr17:84747849-84860671 (+)
C3H/HeJ MGP_C3HHeJ_G0023804
 protein coding gene Chr17:87126017-87241411 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024484
 protein coding gene Chr17:90790454-90904660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021923
 protein coding gene Chr17:80106235-80214993 (+)
CAST/EiJ MGP_CASTEiJ_G0023283
 protein coding gene Chr17:87915622-88033083 (+)
CBA/J MGP_CBAJ_G0023778
 protein coding gene Chr17:94531180-94663530 (+)
DBA/2J MGP_DBA2J_G0023906
 protein coding gene Chr17:83379631-83490986 (+)
FVB/NJ MGP_FVBNJ_G0023872
 protein coding gene Chr17:82859482-82973515 (+)
LP/J MGP_LPJ_G0023990
 protein coding gene Chr17:88437182-88551458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023900
 protein coding gene Chr17:94623582-94741274 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024529
 protein coding gene Chr17:86765245-86880640 (+)
PWK/PhJ MGP_PWKPhJ_G0023028
 protein coding gene Chr17:82946569-83057143 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022839
 protein coding gene Chr17:83579275-83696310 (+)
WSB/EiJ MGP_WSBEiJ_G0023349
 protein coding gene Chr17:87640556-87757383 (+)



Homology
more
  • Human Ortholog
    PLEKHH2, pleckstrin homology, MyTH4 and FERM domain containing H2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHH2, pleckstrin homology, MyTH4 and FERM domain containing H2
  • Synonyms
    PLEKHH1L
  • Links
    NCBI Gene ID: 130271
    neXtProt AC: NX_Q8IVE3
    UniProt: Q8IVE3

  • Chr Location
    2p21; chr2:43637260-43767987 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    29
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040852 Ensembl Gene Model | MGI Sequence Detail 110244 C57BL/6J ±  kb
transcript ENSMUST00000047206 Ensembl | MGI Sequence Detail 6882 Not Applicable  
polypeptide ENSMUSP00000039628 Ensembl | MGI Sequence Detail 1491 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:196351 Perisic L, et al., Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics. Kidney Int. 2012 Nov;82(10):1071-83
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory