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Tfb1m Gene Detail
Summary
  • Symbol
    Tfb1m
  • Name
    transcription factor B1, mitochondrial
  • Synonyms
    MGC:41387
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146851
    NCBI Gene: 224481
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:3569531-3608056 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 2.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1205 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146851
 protein coding gene Chr17:3569119-3608064 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023099
 protein coding gene Chr17:494255-533874 (-)
A/J MGP_AJ_G0023070
 protein coding gene Chr17:601267-641489 (-)
AKR/J MGP_AKRJ_G0023036
 protein coding gene Chr17:529304-572736 (-)
BALB/cJ MGP_BALBcJ_G0023072
 protein coding gene Chr17:514331-560156 (-)
C3H/HeJ MGP_C3HHeJ_G0022831
 protein coding gene Chr17:606618-650001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023518
 protein coding gene Chr17:641842-681151 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021018
 protein coding gene Chr17:427529-466288 (-)
CAST/EiJ MGP_CASTEiJ_G0022350
 protein coding gene Chr17:590887-632572 (-)
CBA/J MGP_CBAJ_G0022799
 protein coding gene Chr17:612779-655845 (-)
DBA/2J MGP_DBA2J_G0022934
 protein coding gene Chr17:455518-494437 (-)
FVB/NJ MGP_FVBNJ_G0022908
 protein coding gene Chr17:480233-519037 (-)
LP/J MGP_LPJ_G0023003
 protein coding gene Chr17:640144-680033 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022929
 protein coding gene Chr17:569033-608379 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023535
 protein coding gene Chr17:519118-558582 (-)
PWK/PhJ MGP_PWKPhJ_G0022095
 protein coding gene Chr17:496154-533785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021923
 protein coding gene Chr17:471704-513692 (-)
WSB/EiJ MGP_WSBEiJ_G0022401
 protein coding gene Chr17:525341-566412 (-)



Homology
more
  • Human Ortholog
    TFB1M, transcription factor B1, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFB1M, transcription factor B1, mitochondrial
  • Synonyms
    CGI-75, CGI75, mtTFB, mtTFB1
  • Links
    NCBI Gene ID: 51106
    neXtProt AC: NX_Q8WVM0
    UniProt: Q8WVM0

  • Chr Location
    6q25.3; chr6:155229871-155314493 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with developmental defects and reduced mitochondrial function at E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    8
  • cDNA Data
    26
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036983 Ensembl Gene Model | MGI Sequence Detail 38526 C57BL/6J ±  kb
    transcript ENSMUST00000041003 Ensembl | MGI Sequence Detail 1402 Not Applicable  
    polypeptide ENSMUSP00000035291 Ensembl | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016267 dimethyladenosine transferase 1, mitochondrial
      (term hierarchy)
    • PDB
      4GC5, 4GC9, 7PNT
    • EC
      2.1.1.-
    • InterPro Domains
      IPR011530 Ribosomal RNA adenine dimethylase
      IPR020596 Ribosomal RNA adenine methylase transferase, conserved site
      IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
      IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm
      IPR023165 rRNA adenine dimethylase-like, C-terminal
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:81452 Rantanen A, et al., Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. Mamm Genome. 2003 Jan;14(1):1-6
    • Latest
      J:319888 Son JS, et al., Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. EBioMedicine. 2022 Jan 23;76:103842
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory