Cyp4f15 Gene Detail

Summary

• Symbol
  Cyp4f15
• Name
  cytochrome P450, family 4, subfamily f, polypeptide 15

• Feature Type
  protein coding gene
• IDs
  MGI:2146921
  NCBI Gene: 106648
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr17:32904605-32922329 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 17.76 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  655 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146921	protein coding gene	Chr17:32904601-32922329 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023510	protein coding gene	Chr17:32557137-32575069 (+)
A/J	MGP_AJ_G0023468	protein coding gene	Chr17:31478232-31496127 (+)
AKR/J	MGP_AKRJ_G0023434	protein coding gene	Chr17:31774296-31793877 (+)
BALB/cJ	MGP_BALBcJ_G0023473	protein coding gene	Chr17:31584568-31602175 (+)
C3H/HeJ	MGP_C3HHeJ_G0023235	protein coding gene	Chr17:32174368-32200489 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023916	protein coding gene	Chr17:33646596-33663599 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021390	protein coding gene	Chr17:28553021-28568544 (+)
CAST/EiJ	MGP_CASTEiJ_G0022736	protein coding gene	Chr17:32270069-32290461 (+)
CBA/J	MGP_CBAJ_G0023209	protein coding gene	Chr17:35159461-35180784 (+)
DBA/2J	MGP_DBA2J_G0023339	protein coding gene	Chr17:30858041-30875984 (+)
FVB/NJ	MGP_FVBNJ_G0023309	protein coding gene	Chr17:30673012-30691399 (+)
LP/J	MGP_LPJ_G0023418	protein coding gene	Chr17:32765084-32784619 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023328	protein coding gene	Chr17:34167142-34189620 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023958	protein coding gene	Chr17:32143115-32161882 (+)
PWK/PhJ	MGP_PWKPhJ_G0022483	protein coding gene	Chr17:29771313-29790508 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022303	protein coding gene	Chr17:30129613-30145447 (+)
WSB/EiJ	MGP_WSBEiJ_G0022797	protein coding gene	Chr17:32147923-32166897 (+)

Homology

• Human Ortholog
  CYP4F11, cytochrome P450 family 4 subfamily F member 11

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CYP4F11, cytochrome P450 family 4 subfamily F member 11
  
• Synonyms
  CYPIVF11
• Links
  HGNC:13265

  NCBI Gene ID: 57834

  neXtProt AC: NX_Q9HBI6

  UniProt: Q9HBI6

  
  
• Chr Location
  19p13.12; chr19:15912367-15934867 (-)  GRCh38

---

• Human Ortholog
  CYP4F2, cytochrome P450 family 4 subfamily F member 2
  
• Synonyms
  CPF2
• Links
  HGNC:2645

  NCBI Gene ID: 8529

  neXtProt AC: NX_P78329

  UniProt: P78329

  
  
• Chr Location
  19p13.12; chr19:15878023-15898077 (-)  GRCh38

---

• Human Ortholog
  CYP4F8, cytochrome P450 family 4 subfamily F member 8
  
• Synonyms
  CPF8, CYPIVF8
• Links
  HGNC:2648

  NCBI Gene ID: 11283

  neXtProt AC: NX_P98187

  UniProt: P98187

  
  
• Chr Location
  19p13.12; chr19:15615218-15630639 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cyp4f15 stringent orthology
  3 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CYP4F11, CYP4F2, CYP4F8
• Gene Tree
  Cyp4f15
  

Human Diseases

• Diseases
  1 with human CYP4F8 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma       DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  2
• Targeted
  2
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  19 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  23
• GO References
  3

Expression

• Assay Results
  800
• Tissues
  94
• cDNA Data
  14
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  38
• RefSeq
  6
• UniProt
  2
• CCDS
  CCDS28620.1, CCDS84293.1

• Ensembl
  ENSMUSG00000073424 (Evidence)
• NCBI Gene
  106648

Representative Sequences			Length	Strain/Species
genomic	106648	NCBI Gene Model | MGI Sequence Detail	17725	C57BL/6J
transcript	NM_134127	RefSeq | MGI Sequence Detail	2157	129T1/Sv-Oca2<+> Tyr Dnd1/J
polypeptide	NP_598888	RefSeq | MGI Sequence Detail	534	129T1/Sv-Oca2<+> Tyr Dnd1/J

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR001128 Cytochrome P450
  IPR017972 Cytochrome P450, conserved site
  IPR002401 Cytochrome P450, E-class, group I
  IPR050196 Cytochrome P450 Monooxygenases
  IPR036396 Cytochrome P450 superfamily

Molecular
Reagents

• All nucleic 16

  cDNA 14

  Primer pair 1

  Other 1

  
  

  Microarray probesets 3

References

• Summaries
  All 23

  Developmental Gene Expression 1

  Gene Ontology 3

  Phenotypes 3
• Earliest
  J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Cyp4f15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143733	Chr17:32904559-32904570 (+)	-40 bp
Tssr143734	Chr17:32904584-32904589 (+)	-18 bp
Tssr143735	Chr17:32904613-32904617 (+)	10 bp
Tssr143736	Chr17:32904629-32904651 (+)	35 bp
Tssr143737	Chr17:32905067-32905080 (+)	469 bp