Ttbk1 MGI Mouse Gene Detail - MGI:2147036

Symbol

Ttbk1
Name

tau tubulin kinase 1
Synonyms

C330008L01Rik

Feature Type

protein coding gene
IDs

MGI:2147036
NCBI Gene: 106763
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:46753374-46798601 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.90 cM
Mapping Data

2 experiments

SNPs within 2kb

974 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147036	protein coding gene	Chr17:46751577-46798601 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023817	protein coding gene	Chr17:47493575-47540618 (-)
A/J	MGP_AJ_G0023775	protein coding gene	Chr17:46362685-46408590 (-)
AKR/J	MGP_AKRJ_G0023746	protein coding gene	Chr17:46705134-46750203 (-)
BALB/cJ	MGP_BALBcJ_G0023779	protein coding gene	Chr17:46262184-46310541 (-)
C3H/HeJ	MGP_C3HHeJ_G0023542	protein coding gene	Chr17:47445530-47491009 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024222	protein coding gene	Chr17:49554438-49600850 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021672	protein coding gene	Chr17:43153160-43198316 (-)
CAST/EiJ	MGP_CASTEiJ_G0023024	protein coding gene	Chr17:47523027-47571852 (-)
CBA/J	MGP_CBAJ_G0023519	protein coding gene	Chr17:51331286-51376408 (-)
DBA/2J	MGP_DBA2J_G0023645	protein coding gene	Chr17:45143498-45189333 (-)
FVB/NJ	MGP_FVBNJ_G0023612	protein coding gene	Chr17:44756470-44802417 (-)
LP/J	MGP_LPJ_G0023726	protein coding gene	Chr17:48184065-48230185 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023641	protein coding gene	Chr17:50888662-50935919 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024267	protein coding gene	Chr17:47057629-47103693 (-)
PWK/PhJ	MGP_PWKPhJ_G0022769	protein coding gene	Chr17:44479024-44524178 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022584	protein coding gene	Chr17:43931348-43980748 (-)
WSB/EiJ	MGP_WSBEiJ_G0023089	protein coding gene	Chr17:47603427-47651681 (-)

Human Ortholog

TTBK1, tau tubulin kinase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TTBK1, tau tubulin kinase 1
Synonyms

BDTK
Links

HGNC:19140

NCBI Gene ID: 84630

neXtProt AC: NX_Q5TCY1

UniProt: Q5TCY1
Chr Location

6p21.1; chr6:43243481-43288258 (+) GRCh38

MGI Vertebrate Homology

Ttbk1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TTBK1
Gene Tree

Ttbk1

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

62
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

11
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

48
RefSeq

8
UniProt

5
CCDS

CCDS50125.1

Ensembl

ENSMUSG00000015599 (Evidence)
NCBI Gene

106763

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015599	Ensembl Gene Model \| MGI Sequence Detail	45228	C57BL/6J	± kb
transcript	ENSMUST00000047034	Ensembl \| MGI Sequence Detail	6959	Not Applicable
polypeptide	ENSMUSP00000044580	Ensembl \| MGI Sequence Detail	1308	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016777 tau-tubulin kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR050235 Casein Kinase 1 Ser/Thr Protein Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR042714 Tau-tubulin kinase 1, catalytic domain
GlyGen

Q6PCN3 1 site, 1 O-linked glycan (1 site)

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All nucleic 6

cDNA 6

Microarray probesets 4

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MGI:2146972

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ttbk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148327	Chr17:46798567-46798608 (-)	13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24