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Treml2 Gene Detail
Summary
  • Symbol
    Treml2
  • Name
    triggering receptor expressed on myeloid cells-like 2
  • Synonyms
    LOC328833
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147038
    NCBI Gene: 328833
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48606526-48619561 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147038
 protein coding gene Chr17:48606419-48619562 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023867
 protein coding gene Chr17:49569980-49584024 (+)
A/J MGP_AJ_G0023827
 protein coding gene Chr17:48277053-48289291 (+)
AKR/J MGP_AKRJ_G0023795
 protein coding gene Chr17:48747393-48759261 (+)
BALB/cJ MGP_BALBcJ_G0023829
 protein coding gene Chr17:48196749-48209354 (+)
C3H/HeJ MGP_C3HHeJ_G0023592
 protein coding gene Chr17:49455443-49474864 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024272
 protein coding gene Chr17:51680554-51700081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021721
 protein coding gene Chr17:45035414-45048302 (+)
CAST/EiJ MGP_CASTEiJ_G0023074
 protein coding gene Chr17:49641586-49653428 (+)
CBA/J MGP_CBAJ_G0023568
 protein coding gene Chr17:53521520-53563431 (+)
DBA/2J MGP_DBA2J_G0023697
 protein coding gene Chr17:47043665-47068009 (+)
FVB/NJ MGP_FVBNJ_G0023663
 protein coding gene Chr17:46708642-46720672 (+)
LP/J MGP_LPJ_G0023777
 protein coding gene Chr17:50275894-50288663 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023691
 protein coding gene Chr17:53022358-53034436 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024318
 protein coding gene Chr17:49085251-49098121 (+)
PWK/PhJ MGP_PWKPhJ_G0022819
 protein coding gene Chr17:46476432-46491481 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022633
 protein coding gene Chr17:45989340-46002574 (+)
WSB/EiJ MGP_WSBEiJ_G0023138
 protein coding gene Chr17:49675710-49687793 (+)



Homology
more
  • Human Ortholog
    TREML2, triggering receptor expressed on myeloid cells like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TREML2, triggering receptor expressed on myeloid cells like 2
  • Synonyms
    C6orf76, dJ238O23.1, TLT-2, TLT2
  • Links
    NCBI Gene ID: 79865
    neXtProt AC: NX_Q5T2D2
    UniProt: Q5T2D2

  • Chr Location
    6p21.1; chr6:41189749-41201149 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071068 Ensembl Gene Model | MGI Sequence Detail 13036 C57BL/6J ±  kb
transcript ENSMUST00000233092 Ensembl | MGI Sequence Detail 2094 Not Applicable  
polypeptide ENSMUSP00000156527 Ensembl | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 9

    Microarray probesets 6
Other
Accession IDs
less
MGI:2685596
References
more
  • Summaries
    All 33
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:348462 Wang SY, et al., The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation. Neural Regen Res. 2023 Feb;18(2):434-438
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory