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Tnfaip8 Gene Detail
Summary
  • Symbol
    Tnfaip8
  • Name
    tumor necrosis factor, alpha-induced protein 8
  • Synonyms
    E130304C20Rik, Gg2-1, Gm10539, Nded, Ssc-2, Tipe
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147191
    NCBI Gene: 106869
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:50112494-50226296 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 27.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3384 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147191
 protein coding gene Chr18:50112494-50240240 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024420
 protein coding gene Chr18:48992608-49127569 (+)
A/J MGP_AJ_G0024386
 protein coding gene Chr18:47139833-47271792 (+)
AKR/J MGP_AKRJ_G0024356
 protein coding gene Chr18:48448034-48583689 (+)
BALB/cJ MGP_BALBcJ_G0024386
 protein coding gene Chr18:47269090-47400443 (+)
C3H/HeJ MGP_C3HHeJ_G0024153
 protein coding gene Chr18:48578480-48712370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024832
 protein coding gene Chr18:50635539-50769806 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022265
 protein coding gene Chr18:46844780-46958335 (+)
CAST/EiJ MGP_CASTEiJ_G0023628
 protein coding gene Chr18:48555797-48688864 (+)
CBA/J MGP_CBAJ_G0024123
 protein coding gene Chr18:52108732-52255409 (+)
DBA/2J MGP_DBA2J_G0024253
 protein coding gene Chr18:46782372-46911522 (+)
FVB/NJ MGP_FVBNJ_G0024220
 protein coding gene Chr18:46333332-46462780 (+)
LP/J MGP_LPJ_G0024338
 protein coding gene Chr18:49012311-49147567 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024250
 protein coding gene Chr18:53642059-53774439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024879
 protein coding gene Chr18:48413868-48546590 (+)
PWK/PhJ MGP_PWKPhJ_G0023371
 protein coding gene Chr18:46908443-47040566 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023177
 protein coding gene Chr18:48627676-48779105 (+)
WSB/EiJ MGP_WSBEiJ_G0023691
 protein coding gene Chr18:48302972-48437131 (+)



Homology
more
  • Human Ortholog
    TNFAIP8, TNF alpha induced protein 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFAIP8, TNF alpha induced protein 8
  • Synonyms
    GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2
  • Links
    NCBI Gene ID: 25816
    neXtProt AC: NX_O95379
    UniProt: O95379

  • Chr Location
    5q23.1; chr5:119268692-119399688 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    18
  • cDNA Data
    88
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106869 NCBI Gene Model | MGI Sequence Detail 113803 C57BL/6J ±  kb
    transcript NM_001360935 RefSeq | MGI Sequence Detail 3410 C57BL/6  
    polypeptide Q921Z5 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000016476 tumor necrosis factor alpha-induced protein 8
      (term hierarchy)
    • PDB
      5JXD
    • InterPro Domains
      IPR008477 Tumor necrosis factor alpha-induced protein 8-like
      IPR038355 Tumor necrosis factor alpha-induced protein 8-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3642692
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:342074 Lou Y, et al., Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation. J Immunol. 2023 Sep 1;211(5):874-884
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory