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Slc39a6 Gene Detail
Summary
  • Symbol
    Slc39a6
  • Name
    solute carrier family 39 (metal ion transporter), member 6
  • Synonyms
    Ermelin, Zip6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147279
    NCBI Gene: 106957
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:24712938-24736874 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 13.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    643 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147279
 protein coding gene Chr18:24712938-24736874 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024202
 protein coding gene Chr18:22340925-22374149 (-)
A/J MGP_AJ_G0024167
 protein coding gene Chr18:21712318-21744500 (-)
AKR/J MGP_AKRJ_G0024136
 protein coding gene Chr18:22355946-22385495 (-)
BALB/cJ MGP_BALBcJ_G0024167
 protein coding gene Chr18:21775522-21808240 (-)
C3H/HeJ MGP_C3HHeJ_G0023935
 protein coding gene Chr18:22304924-22329224 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024609
 protein coding gene Chr18:23277064-23302494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022051
 protein coding gene Chr18:21563541-21588416 (-)
CAST/EiJ MGP_CASTEiJ_G0023409
 protein coding gene Chr18:22090849-22116431 (-)
CBA/J MGP_CBAJ_G0023903
 protein coding gene Chr18:23885907-23920464 (-)
DBA/2J MGP_DBA2J_G0024035
 protein coding gene Chr18:21369975-21393921 (-)
FVB/NJ MGP_FVBNJ_G0024001
 protein coding gene Chr18:21151557-21177778 (-)
LP/J MGP_LPJ_G0024116
 protein coding gene Chr18:22501771-22526728 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024029
 protein coding gene Chr18:24900892-24934123 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024657
 protein coding gene Chr18:22133074-22161176 (-)
PWK/PhJ MGP_PWKPhJ_G0023153
 protein coding gene Chr18:21514299-21538877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022962
 protein coding gene Chr18:22355285-22380521 (-)
WSB/EiJ MGP_WSBEiJ_G0023473
 protein coding gene Chr18:22019829-22043692 (-)



Homology
more
  • Human Ortholog
    SLC39A6, solute carrier family 39 member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A6, solute carrier family 39 member 6
  • Synonyms
    LIV-1, LIV1, ZIP6
  • Links
    NCBI Gene ID: 25800
    neXtProt AC: NX_Q13433
    UniProt: Q13433

  • Chr Location
    18q12.2; chr18:36108531-36129385 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous for a null allele do not display any gross skin abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    79
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106957 NCBI Gene Model | MGI Sequence Detail 23937 C57BL/6J ±  kb
transcript NM_139143 RefSeq | MGI Sequence Detail 3905 C57BL/6  
polypeptide Q8C145 UniProt | EBI | MGI Sequence Detail 765 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 79
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:75677 Suzuki A, et al., Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes. Gene. 2002 Feb 6;284(1-2):31-40
  • Latest
    J:349645 Chen P, et al., The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis. EBioMedicine. 2019 Nov;49:26-39
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory