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Wdr74 Gene Detail
Summary
  • Symbol
    Wdr74
  • Name
    WD repeat domain 74
  • Synonyms
    5730436H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147427
    NCBI Gene: 107071
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8713191-8717988 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147427
 protein coding gene Chr19:8713159-8717988 (+)
129S1/SvImJ ENSMUSG00200047568
 protein coding gene Chr19:5438925-5443722 (+)
A/J ENSMUSG00195047326
 protein coding gene Chr19:5840420-5845217 (+)
AKR/J ENSMUSG00220048457
 protein coding gene Chr19:5613661-5618459 (+)
BALB/cJ ENSMUSG00180037779
 protein coding gene Chr19:6204404-6209201 (+)
C3H/HeJ ENSMUSG00175012941
 protein coding gene Chr19:5478159-5482956 (+)
C57BL/6NJ ENSMUSG00215045898
 protein coding gene Chr19:5679369-5684166 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022648
 protein coding gene Chr19:5929271-5933882 (+)
CAST/EiJ ENSTCUG00005026275
 protein coding gene Chr19:5316558-5321140 (+)
CBA/J ENSMUSG00210039811
 protein coding gene Chr19:5494088-5498678 (+)
DBA/2J ENSMUSG00185051401
 protein coding gene Chr19:5848776-5853366 (+)
FVB/NJ ENSMUSG00205046951
 protein coding gene Chr19:5536369-5541165 (+)
JF1/MsJ ENSUMUG00000052505
 protein coding gene Chr19:6085809-6090407 (+)
LP/J ENSMUSG00230052215
 protein coding gene Chr19:6765584-6770380 (+)
NOD/ShiLtJ ENSMUSG00190044357
 protein coding gene Chr19:5373975-5378772 (+)
NZO/HlLtJ ENSMUSG00225044626
 protein coding gene Chr19:10474382-10479179 (+)
PWK/PhJ ENSLUMG00010003873
 protein coding gene Chr19:5522063-5526661 (+)
SPRET/EiJ ENSMSPG00010041101
 protein coding gene Chr19:5426420-5431018 (+)
WSB/EiJ ENSIUOG00005049252
 protein coding gene Chr19:5202665-5207460 (+)



Homology
more
  • Human Ortholog
    WDR74, WD repeat domain 74
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR74, WD repeat domain 74
  • Synonyms
    Nsa1
  • Links
    NCBI Gene ID: 54663
    UniProt: Q6RFH5

  • Chr Location
    11q12.3; chr11:62832342-62842228 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    10
  • cDNA Data
    63
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042729 Ensembl Gene Model | MGI Sequence Detail 4798 C57BL/6J ±  kb
transcript ENSMUST00000049424 Ensembl | MGI Sequence Detail 1204 Not Applicable  
polypeptide ENSMUSP00000043315 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 63
    Primer pair 2
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory