Btaf1 MGI Mouse Gene Detail - MGI:2147538 - B-TFIID TATA-box binding protein associated factor 1

Symbol

Btaf1
Name

B-TFIID TATA-box binding protein associated factor 1
Synonyms

E430027O22Rik

Feature Type

protein coding gene
IDs

MGI:2147538
NCBI Gene: 107182
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:36903479-36990152 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.02 cM
Mapping Data

2 experiments

SNPs within 2kb

1886 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147538	protein coding gene	Chr19:36903479-36991457 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025076	protein coding gene	Chr19:35842689-35940566 (+)
A/J	MGP_AJ_G0025052	protein coding gene	Chr19:34122844-34212709 (+)
AKR/J	MGP_AKRJ_G0025020	protein coding gene	Chr19:35279543-35377900 (+)
BALB/cJ	MGP_BALBcJ_G0025050	protein coding gene	Chr19:34207487-34297508 (+)
C3H/HeJ	MGP_C3HHeJ_G0024809	protein coding gene	Chr19:35337779-35431195 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025491	protein coding gene	Chr19:36875069-36975164 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022909	protein coding gene	Chr19:33486431-33573659 (+)
CAST/EiJ	MGP_CASTEiJ_G0024276	protein coding gene	Chr19:35171094-35267078 (+)
CBA/J	MGP_CBAJ_G0024786	protein coding gene	Chr19:38626784-38722956 (+)
DBA/2J	MGP_DBA2J_G0024918	protein coding gene	Chr19:33981611-34068858 (+)
FVB/NJ	MGP_FVBNJ_G0024879	protein coding gene	Chr19:33790342-33880721 (+)
LP/J	MGP_LPJ_G0025004	protein coding gene	Chr19:35938675-36045127 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024910	protein coding gene	Chr19:38450309-38547753 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025549	protein coding gene	Chr19:35370919-35464698 (+)
PWK/PhJ	MGP_PWKPhJ_G0024028	protein coding gene	Chr19:33811996-33903428 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023828	protein coding gene	Chr19:34195095-34287601 (+)
WSB/EiJ	MGP_WSBEiJ_G0024343	protein coding gene	Chr19:35463584-35553592 (+)

Human Ortholog

BTAF1, B-TFIID TATA-box binding protein associated factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BTAF1, B-TFIID TATA-box binding protein associated factor 1
Synonyms

MOT1, TAF172, TAF(II)170, TAFII170
Links

HGNC:17307

NCBI Gene ID: 9044

neXtProt AC: NX_O14981

UniProt: O14981
Chr Location

10q23.32; chr10:91923770-92031437 (+) GRCh38

MGI Vertebrate Homology

Btaf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BTAF1
Gene Tree

Btaf1

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Phenotype Summary

7 phenotypes from 2 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

51
Chemically induced (ENU)

1
Gene trapped

48
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

109 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a gene-trapped allele display growth retardation. Embryos homozygous for an ENU-induced allele show growth retardation, edema, abnormal blood circulation, myocardial trabeculae hypoplasia, and delayed head and brain development.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

17
cDNA Data

124
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase btaf1

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All Sequences

52
RefSeq

10
UniProt

4
CCDS

CCDS37969.1

Ensembl

ENSMUSG00000040565 (Evidence)
NCBI Gene

107182

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040565	Ensembl Gene Model \| MGI Sequence Detail	86674	C57BL/6J	± kb
transcript	ENSMUST00000099494	Ensembl \| MGI Sequence Detail	7204	Not Applicable
polypeptide	ENSMUSP00000097093	Ensembl \| MGI Sequence Detail	1848	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR000357 HEAT repeat

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR044078 Mot1, ATP-binding domain

IPR022707 Mot1, central domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR038718 SNF2-like, N-terminal domain superfamily

IPR000330 SNF2, N-terminal

IPR049730 SNF2/RAD5-like, C-terminal helicase domain

IPR044972 TATA-binding protein-associated factor Mot1
GlyGen

E9QAE3 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 126

cDNA 124

Primer pair 1

Other 1

Microarray probesets 6

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MGI:2147520

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:173663 Wansleeben C, et al., An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Mech Dev. 2011 May-Jun;128(5-6):279-88

TSS for Btaf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156204	Chr19:36903471-36903577 (+)	45 bp
Tssr156205	Chr19:36904069-36904074 (+)	593 bp
Tssr156206	Chr19:36905405-36905413 (+)	1,930 bp
Tssr156207	Chr19:36907429-36907432 (+)	3,952 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24