Ffar4 MGI Mouse Gene Detail - MGI:2147577 - free fatty acid receptor 4

Symbol

Ffar4
Name

free fatty acid receptor 4
Synonyms

Ffa4, Gpr120, Gpr129, O3far1, Pgr4

Feature Type

protein coding gene
IDs

MGI:2147577
NCBI Gene: 107221
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:38085527-38102711 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.73 cM
Mapping Data

1 experiment

SNPs within 2kb

612 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147577	protein coding gene	Chr19:38085519-38102711 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025087	protein coding gene	Chr19:37115084-37134834 (+)
A/J	MGP_AJ_G0025063	protein coding gene	Chr19:35314909-35332509 (+)
AKR/J	MGP_AKRJ_G0025031	protein coding gene	Chr19:36516379-36534005 (+)
BALB/cJ	MGP_BALBcJ_G0025061	protein coding gene	Chr19:35420795-35441120 (+)
C3H/HeJ	MGP_C3HHeJ_G0024820	protein coding gene	Chr19:36587030-36606523 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025502	protein coding gene	Chr19:38181981-38198995 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022921	protein coding gene	Chr19:34669815-34688042 (+)
CAST/EiJ	MGP_CASTEiJ_G0024287	protein coding gene	Chr19:36458150-36475213 (+)
CBA/J	MGP_CBAJ_G0024797	protein coding gene	Chr19:39961070-39980235 (+)
DBA/2J	MGP_DBA2J_G0024929	protein coding gene	Chr19:35168174-35186323 (+)
FVB/NJ	MGP_FVBNJ_G0024890	protein coding gene	Chr19:34977221-34999065 (+)
LP/J	MGP_LPJ_G0025015	protein coding gene	Chr19:37213696-37232474 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024921	protein coding gene	Chr19:39739249-39760934 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025560	protein coding gene	Chr19:36615141-36632794 (+)
PWK/PhJ	MGP_PWKPhJ_G0024039	protein coding gene	Chr19:35033967-35052075 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023839	protein coding gene	Chr19:35452968-35469828 (+)
WSB/EiJ	MGP_WSBEiJ_G0024354	protein coding gene	Chr19:36694969-36715444 (+)

Human Ortholog

FFAR4, free fatty acid receptor 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FFAR4, free fatty acid receptor 4
Synonyms

BMIQ10, GPR120, GPR129, GT01, O3FAR1, OB10Q, PGR4
Links

HGNC:19061

NCBI Gene ID: 338557

neXtProt AC: NX_Q5NUL3

UniProt: Q5NUL3
Chr Location

10q23.33; chr10:93566665-93604480 (+) GRCh38

MGI Vertebrate Homology

Ffar4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FFAR4
Gene Tree

Ffar4

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Phenotype Summary

35 phenotypes from 5 alleles in 5 genetic backgrounds
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

10
Gene trapped

4
Targeted

16
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show altered taste responses to fatty acids. Homozygotes for another null allele develop obesity, liver steatosis, and impaired glucose metabolism, adipogenesis and lipogenesis on a high-fat diet. Homozygotes for a third allele show altered islet somatostatin secretion.

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All GO Annotations

49
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

18
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS29783.1

Ensembl

ENSMUSG00000054200 (Evidence)
NCBI Gene

107221

			Length	Strain/Species	Flank
genomic	107221	NCBI Gene Model \| MGI Sequence Detail	17185	C57BL/6J	± kb
transcript	NM_181748	RefSeq \| MGI Sequence Detail	1393	C57BL/6
polypeptide	Q7TMA4	UniProt \| EBI \| MGI Sequence Detail	361	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001417 free fatty acid receptor 4

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q7TMA4 1 site

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

Summaries

All 106

Developmental Gene Expression 2

Gene Ontology 21

Phenotypes 54
Earliest

J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
Latest

J:347158 Hagihara M, et al., Oral Clostridium butyricum on mice endometritis through uterine microbiome and metabolic alternations. Front Microbiol. 2024;15:1351899

TSS for Ffar4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156242	Chr19:38085306-38085337 (+)	-205 bp
Tssr156243	Chr19:38085513-38085552 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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