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Spindoc Gene Detail
Summary
  • Symbol
    Spindoc
  • Name
    spindlin interactor and repressor of chromatin binding
  • Synonyms
    AI846148
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147611
    NCBI Gene: 68229
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7331443-7360359 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    813 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147611
 protein coding gene Chr19:7331443-7364491 (-)
129S1/SvImJ ENSMUSG00200042870
 protein coding gene Chr19:4056988-4085909 (-)
A/J ENSMUSG00195051115
 protein coding gene Chr19:4458918-4487839 (-)
AKR/J ENSMUSG00220045967
 protein coding gene Chr19:4228295-4257214 (-)
BALB/cJ ENSMUSG00180050789
 protein coding gene Chr19:4822438-4851358 (-)
C3H/HeJ ENSMUSG00175012488
 protein coding gene Chr19:4078908-4107823 (-)
C57BL/6NJ ENSMUSG00215046689
 protein coding gene Chr19:4297424-4326341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022637
 protein coding gene Chr19:4039381-4067080 (-)
CAST/EiJ ENSTCUG00005035619
 protein coding gene Chr19:4199239-4228374 (-)
CBA/J ENSMUSG00210050027
 protein coding gene Chr19:4082042-4110956 (-)
DBA/2J ENSMUSG00185048955
 protein coding gene Chr19:4458514-4487426 (-)
FVB/NJ ENSMUSG00205049785
 protein coding gene Chr19:4456872-4485899 (-)
JF1/MsJ ENSUMUG00000049057
 protein coding gene Chr19:4421329-4447862 (-)
LP/J ENSMUSG00230054139
 protein coding gene Chr19:5383702-5412619 (-)
NOD/ShiLtJ ENSMUSG00190051325
 protein coding gene Chr19:3990161-4019078 (-)
NZO/HlLtJ ENSMUSG00225024943
 protein coding gene Chr19:9092522-9121440 (-)
PWK/PhJ ENSLUMG00010006433
 protein coding gene Chr19:4185012-4211461 (-)
SPRET/EiJ ENSMSPG00010035948
 protein coding gene Chr19:4183037-4208782 (-)
WSB/EiJ ENSIUOG00005043746
 protein coding gene Chr19:4096352-4125439 (-)



Homology
more
  • Human Ortholog
    SPINDOC, spindlin interactor and repressor of chromatin binding
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINDOC, spindlin interactor and repressor of chromatin binding
  • Synonyms
    C11orf84, SPIN-DOC
  • Links
    NCBI Gene ID: 144097
    UniProt: Q9BUA3

  • Chr Location
    11q13.1; chr11:63813433-63827718 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations of this gene are viable but exhibit decreased body weight, reduced levels of PARylation, and increased sensitivity to ionizing radiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024970 Ensembl Gene Model | MGI Sequence Detail 28917 C57BL/6J ±  kb
    transcript ENSMUST00000025924 Ensembl | MGI Sequence Detail 3152 Not Applicable  
    polypeptide ENSMUSP00000025924 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000060048 spindlin interactor and repressor of chromatin-binding protein
      (term hierarchy)
    • InterPro Domains
      IPR040647 SPIN-DOC-like, zinc-finger
      IPR052675 Zinc finger translocation-associated/SPIN-DOC
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:6108113
    References
    more
    • Summaries
      All 32
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:387910 Zhang Z, et al., SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly. Cell Rep. 2026 Jun 22;45(7):117588
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory