Yars1 MGI Mouse Gene Detail - MGI:2147627 - tyrosyl-tRNA synthetase 1

Symbol

Yars1
Name

tyrosyl-tRNA synthetase 1
Synonyms

Yars

Feature Type

protein coding gene
IDs

MGI:2147627
NCBI Gene: 107271
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:129083595-129113033 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.05 cM
Mapping Data

2 experiments

SNPs within 2kb

399 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147627	protein coding gene	Chr4:129083553-129113400 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028816	protein coding gene	Chr4:131056900-131102570 (+)
A/J	MGP_AJ_G0028775	protein coding gene	Chr4:125863411-125893071 (+)
AKR/J	MGP_AKRJ_G0028728	protein coding gene	Chr4:129351608-129385587 (+)
BALB/cJ	MGP_BALBcJ_G0028798	protein coding gene	Chr4:126441463-126472663 (+)
C3H/HeJ	MGP_C3HHeJ_G0028512	protein coding gene	Chr4:129399933-129437245 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029240	protein coding gene	Chr4:136014538-136049138 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026513	protein coding gene	Chr4:118990683-119020778 (+)
CAST/EiJ	MGP_CASTEiJ_G0027945	protein coding gene	Chr4:127583689-127615649 (+)
CBA/J	MGP_CBAJ_G0028478	protein coding gene	Chr4:139336414-139368552 (+)
DBA/2J	MGP_DBA2J_G0028627	protein coding gene	Chr4:126289701-126320482 (+)
FVB/NJ	MGP_FVBNJ_G0028594	protein coding gene	Chr4:125046789-125080863 (+)
LP/J	MGP_LPJ_G0028728	protein coding gene	Chr4:131364750-131395385 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028620	protein coding gene	Chr4:144235311-144265021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029278	protein coding gene	Chr4:129724874-129754249 (+)
PWK/PhJ	MGP_PWKPhJ_G0027666	protein coding gene	Chr4:122865439-122896287 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027493	protein coding gene	Chr4:125582019-125614896 (+)
WSB/EiJ	MGP_WSBEiJ_G0028025	protein coding gene	Chr4:129832294-129864210 (+)

Human Ortholog

YARS1, tyrosyl-tRNA synthetase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YARS1, tyrosyl-tRNA synthetase 1
Synonyms

CMTDIC, IMNEPD2, TYRRS, YARS, YRS, YTS
Links

HGNC:12840

NCBI Gene ID: 8565

neXtProt AC: NX_P54577

UniProt: P54577
Chr Location

1p35.1; chr1:32775237-32818031 (-) GRCh38

MGI Vertebrate Homology

Yars1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YARS1
Gene Tree

Yars1

Diseases

1 with Yars1 mouse models; 1 with human YARS1 associations

Human Disease

Mouse Models

Charcot-Marie-Tooth disease dominant intermediate C

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

65
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

54
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Yars1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

66 strains or lines available

Homozygous p.E196K mutation induces integrated stress response in motor neurons and spinal cord.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

108
cDNA Data

156
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase yars1

ZFIN yars1

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All Sequences

71
RefSeq

4
UniProt

3
CCDS

CCDS18685.2

Ensembl

ENSMUSG00000028811 (Evidence)
NCBI Gene

107271

			Length	Strain/Species	Flank
genomic	107271	NCBI Gene Model \| MGI Sequence Detail	29439	C57BL/6J	± kb
transcript	NR_160965	RefSeq \| MGI Sequence Detail	2404	C57BL/6
polypeptide	Q91WQ3	UniProt \| EBI \| MGI Sequence Detail	528	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017523 tyrosine--tRNA ligase, cytoplasmic

(term hierarchy)
EC

6.1.1.1
InterPro Domains

IPR002305 Aminoacyl-tRNA synthetase, class Ic

IPR012340 Nucleic acid-binding, OB-fold

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

IPR002547 tRNA-binding domain

IPR002307 Tyrosine-tRNA ligase

IPR051270 Tyrosine-tRNA ligase and regulatory protein
GlyGen

Q91WQ3 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 157

cDNA 156

Primer pair 1

Microarray probesets 4

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MGI:2140444, MGI:7482287

Summaries

All 56

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 25
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:357574 Jones JA, et al., Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Sep 12;300(10):107756

TSS for Yars1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39129	Chr4:129083656-129083749 (+)	108 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24