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Afap1l2 Gene Detail
Summary
  • Symbol
    Afap1l2
  • Name
    actin filament associated protein 1-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147658
    NCBI Gene: 226250
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56900793-56996660 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 52.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147658
 protein coding gene Chr19:56900786-57017021 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025271
 protein coding gene Chr19:57294254-57394860 (-)
A/J MGP_AJ_G0025247
 protein coding gene Chr19:54462809-54560105 (-)
AKR/J MGP_AKRJ_G0025216
 protein coding gene Chr19:56183239-56280384 (-)
BALB/cJ MGP_BALBcJ_G0025242
 protein coding gene Chr19:54539396-54635776 (-)
C3H/HeJ MGP_C3HHeJ_G0025002
 protein coding gene Chr19:56418253-56515440 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025685
 protein coding gene Chr19:58673507-58773689 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023097
 protein coding gene Chr19:53387309-53482156 (-)
CAST/EiJ MGP_CASTEiJ_G0024467
 protein coding gene Chr19:56445827-56554498 (-)
CBA/J MGP_CBAJ_G0024982
 protein coding gene Chr19:61581969-61682634 (-)
DBA/2J MGP_DBA2J_G0025114
 protein coding gene Chr19:54246017-54341652 (-)
FVB/NJ MGP_FVBNJ_G0025075
 protein coding gene Chr19:53954991-54055109 (-)
LP/J MGP_LPJ_G0025200
 protein coding gene Chr19:57150628-57251216 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025108
 protein coding gene Chr19:60844745-60944707 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025743
 protein coding gene Chr19:56389039-56486220 (-)
PWK/PhJ MGP_PWKPhJ_G0024215
 protein coding gene Chr19:54215114-54313293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024018
 protein coding gene Chr19:55067116-55166846 (-)
WSB/EiJ MGP_WSBEiJ_G0024537
 protein coding gene Chr19:56526309-56624779 (-)



Homology
more
  • Human Ortholog
    AFAP1L2, actin filament associated protein 1 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFAP1L2, actin filament associated protein 1 like 2
  • Synonyms
    CTB-1144G6.4, KIAA1914, XB130
  • Links
    NCBI Gene ID: 84632
    neXtProt AC: NX_Q8N4X5
    UniProt: Q8N4X5

  • Chr Location
    10q25.3; chr10:114280725-114405175 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a thicker tracheal epithelium and a transient tracheal epithelial hyperplasia during airway repair after injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    960
  • Tissues
    63
  • cDNA Data
    51
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025083 Ensembl Gene Model | MGI Sequence Detail 95868 C57BL/6J ±  kb
    transcript ENSMUST00000111584 Ensembl | MGI Sequence Detail 3597 Not Applicable  
    polypeptide ENSMUSP00000107210 Ensembl | MGI Sequence Detail 843 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147805
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory