Patl1 MGI Mouse Gene Detail - MGI:2147679 - protein associated with topoisomerase II homolog 1 (yeast)

Symbol

Patl1
Name

protein associated with topoisomerase II homolog 1 (yeast)
Synonyms

Pat1b

Feature Type

protein coding gene
IDs

MGI:2147679
NCBI Gene: 225929
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:11889763-11922455 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.57 cM
Mapping Data

1 experiment

SNPs within 2kb

854 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147679	protein coding gene	Chr19:11889728-11922462 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024889	protein coding gene	Chr19:9311256-9344989 (+)
A/J	MGP_AJ_G0024865	protein coding gene	Chr19:8791755-8824250 (+)
AKR/J	MGP_AKRJ_G0024838	protein coding gene	Chr19:9130383-9162795 (+)
BALB/cJ	MGP_BALBcJ_G0024865	protein coding gene	Chr19:8798815-8831384 (+)
C3H/HeJ	MGP_C3HHeJ_G0024629	protein coding gene	Chr19:9022255-9055946 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025313	protein coding gene	Chr19:9767585-9814596 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022739	protein coding gene	Chr19:9374902-9407795 (+)
CAST/EiJ	MGP_CASTEiJ_G0024102	protein coding gene	Chr19:8631347-8665276 (+)
CBA/J	MGP_CBAJ_G0024604	protein coding gene	Chr19:9844779-9883674 (+)
DBA/2J	MGP_DBA2J_G0024732	protein coding gene	Chr19:8756458-8788745 (+)
FVB/NJ	MGP_FVBNJ_G0024697	protein coding gene	Chr19:8787200-8819703 (+)
LP/J	MGP_LPJ_G0024819	protein coding gene	Chr19:9318999-9351842 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024724	protein coding gene	Chr19:9754849-9789401 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025361	protein coding gene	Chr19:9111012-9145865 (+)
PWK/PhJ	MGP_PWKPhJ_G0023847	protein coding gene	Chr19:8229400-8261521 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023652	protein coding gene	Chr19:8284083-8318477 (+)
WSB/EiJ	MGP_WSBEiJ_G0024164	protein coding gene	Chr19:8968235-9005638 (+)

Human Ortholog

PATL1, PAT1 homolog 1, processing body mRNA decay factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PATL1, PAT1 homolog 1, processing body mRNA decay factor
Synonyms

hPat1b, Pat1b
Links

HGNC:26721

NCBI Gene ID: 219988

neXtProt AC: NX_Q86TB9

UniProt: Q86TB9
Chr Location

11q12.1; chr11:59636716-59669037 (-) GRCh38

MGI Vertebrate Homology

Patl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PATL1
Gene Tree

Patl1

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

less

All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase patl1

ZFIN patl1

less

All Sequences

52
RefSeq

9
UniProt

2
CCDS

CCDS37924.1

Ensembl

ENSMUSG00000046139 (Evidence)
NCBI Gene

225929

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046139	Ensembl Gene Model \| MGI Sequence Detail	32693	C57BL/6J	± kb
transcript	ENSMUST00000061618	Ensembl \| MGI Sequence Detail	4216	Not Applicable
polypeptide	ENSMUSP00000060398	Ensembl \| MGI Sequence Detail	770	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000012311 protein PAT1 homolog 1

(term hierarchy)
InterPro Domains

IPR019167 mRNA decay factor PAT1 domain

IPR039900 Pat1-like
GlyGen

Q3TC46 1 site, 1 N-linked glycan (1 site)

less

All nucleic 15

cDNA 15

Microarray probesets 5

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Patl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155289	Chr19:11889616-11889636 (+)	-137 bp
Tssr155290	Chr19:11889654-11889670 (+)	-101 bp
Tssr155291	Chr19:11889672-11889689 (+)	-82 bp
Tssr155292	Chr19:11889695-11889719 (+)	-56 bp
Tssr155293	Chr19:11889753-11889839 (+)	33 bp
Tssr155294	Chr19:11890487-11890499 (+)	730 bp
Tssr155295	Chr19:11898751-11898778 (+)	9,002 bp
Tssr155296	Chr19:11898786-11898797 (+)	9,029 bp
Tssr155297	Chr19:11901304-11901328 (+)	11,553 bp
Tssr155298	Chr19:11920795-11920809 (+)	31,039 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24