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Fermt3 Gene Detail
Summary
  • Symbol
    Fermt3
  • Name
    fermitin family member 3
  • Synonyms
    C79673, Kindlin-3, MGC:36836, MGC:38286
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147790
    NCBI Gene: 108101
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6976326-6996837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    658 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147790
 protein coding gene Chr19:6976326-6996837 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024781
 protein coding gene Chr19:4096896-4126031 (-)
A/J MGP_AJ_G0024748
 protein coding gene Chr19:3762582-3785556 (-)
AKR/J MGP_AKRJ_G0024721
 protein coding gene Chr19:3886194-3912194 (-)
BALB/cJ MGP_BALBcJ_G0024748
 protein coding gene Chr19:3872981-3894985 (-)
C3H/HeJ MGP_C3HHeJ_G0024516
 protein coding gene Chr19:4008469-4031572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025194
 protein coding gene Chr19:4188742-4212128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022628
 protein coding gene Chr19:3668538-3687588 (-)
CAST/EiJ MGP_CASTEiJ_G0023988
 protein coding gene Chr19:3916877-3941250 (-)
CBA/J MGP_CBAJ_G0024488
 protein coding gene Chr19:4243728-4273901 (-)
DBA/2J MGP_DBA2J_G0024615
 protein coding gene Chr19:3733968-3755476 (-)
FVB/NJ MGP_FVBNJ_G0024580
 protein coding gene Chr19:3765479-3785251 (-)
LP/J MGP_LPJ_G0024701
 protein coding gene Chr19:3958877-3983286 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024610
 protein coding gene Chr19:4148630-4177942 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025242
 protein coding gene Chr19:4024393-4048152 (-)
PWK/PhJ MGP_PWKPhJ_G0023734
 protein coding gene Chr19:3778801-3799860 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023538
 protein coding gene Chr19:3837704-3859256 (-)
WSB/EiJ MGP_WSBEiJ_G0024050
 protein coding gene Chr19:3926206-3952083 (-)



Homology
more
  • Human Ortholog
    FERMT3, FERM domain containing kindlin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FERMT3, FERM domain containing kindlin 3
  • Synonyms
    KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF
  • Links
    NCBI Gene ID: 83706
    neXtProt AC: NX_Q86UX7
    UniProt: Q86UX7

  • Chr Location
    11q13.1; chr11:64205920-64223896 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fermt3 mouse models; 2 with human FERMT3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 4 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of this marker results in lethality in the first week after birth, abnormal erythropoiesis and platelet function, and severe hemorrhage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    40
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108101 NCBI Gene Model | MGI Sequence Detail 20512 C57BL/6J ±  kb
    transcript NM_001362399 RefSeq | MGI Sequence Detail 2590 C57BL/6  
    polypeptide Q8K1B8 UniProt | EBI | MGI Sequence Detail 665 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 38
    • Earliest
      J:51223 Spinelli SL, et al., A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14136-41
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory