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Lrch2 Gene Detail
Summary
  • Symbol
    Lrch2
  • Name
    leucine-rich repeats and calponin homology (CH) domain containing 2
  • Synonyms
    mKIAA1495
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147870
    NCBI Gene: 210297
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:146253371-146337077 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1951 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147870
 protein coding gene ChrX:146253371-146337198 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036166
 protein coding gene ChrX:145086291-145332061 (-)
A/J MGP_AJ_G0036142
 protein coding gene ChrX:144342276-144436701 (-)
AKR/J MGP_AKRJ_G0036068
 protein coding gene ChrX:149117314-149361770 (-)
BALB/cJ MGP_BALBcJ_G0036133
 protein coding gene ChrX:142558831-142652600 (-)
C3H/HeJ MGP_C3HHeJ_G0035841
 protein coding gene ChrX:145200400-145435381 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036658
 protein coding gene ChrX:149181814-149267953 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033482
 protein coding gene ChrX:135790039-135880343 (-)
CAST/EiJ MGP_CASTEiJ_G0035132
 protein coding gene ChrX:125732625-125832510 (-)
CBA/J MGP_CBAJ_G0035818
 protein coding gene ChrX:153826359-153937858 (-)
DBA/2J MGP_DBA2J_G0035976
 protein coding gene ChrX:143401402-143527730 (-)
FVB/NJ MGP_FVBNJ_G0035910
 protein coding gene ChrX:142617848-142708146 (-)
LP/J MGP_LPJ_G0036067
 protein coding gene ChrX:145993950-146087817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035946
 protein coding gene ChrX:161929690-162042160 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036693
 protein coding gene ChrX:144349635-144445676 (-)
PWK/PhJ MGP_PWKPhJ_G0034826
 protein coding gene ChrX:122477196-122566899 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034652
 protein coding gene ChrX:126295287-126383665 (-)
WSB/EiJ MGP_WSBEiJ_G0035267
 protein coding gene ChrX:142647590-142741960 (-)



Homology
more
  • Human Ortholog
    LRCH2, leucine rich repeats and calponin homology domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRCH2, leucine rich repeats and calponin homology domain containing 2
  • Synonyms
    dA204F4.4
  • Links
    NCBI Gene ID: 57631
    neXtProt AC: NX_Q5VUJ6
    UniProt: Q5VUJ6

  • Chr Location
    Xq23; chrX:115110616-115234096 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    9
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031290 Ensembl Gene Model | MGI Sequence Detail 83707 C57BL/6J ±  kb
    transcript ENSMUST00000136789 Ensembl | MGI Sequence Detail 4930 Not Applicable  
    polypeptide ENSMUSP00000123633 Ensembl | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 4
      Phenotypes 10
    • Earliest
      J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory