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Ces1d Gene Detail
Summary
  • Symbol
    Ces1d
  • Name
    carboxylesterase 1D
  • Synonyms
    Ces3, TGH
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148202
    NCBI Gene: 104158
  • Member of
    Ces1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:93892700-93924432 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 45.05 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1058 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148202
 protein coding gene Chr8:93892696-93924466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033943
 protein coding gene Chr8:94534336-94568459 (-)
A/J MGP_AJ_G0033926
 protein coding gene Chr8:90832679-90866699 (-)
AKR/J MGP_AKRJ_G0033852
 protein coding gene Chr8:93331609-93364494 (-)
BALB/cJ MGP_BALBcJ_G0033918
 protein coding gene Chr8:90935622-90969903 (-)
C3H/HeJ MGP_C3HHeJ_G0033628
 protein coding gene Chr8:94035001-94068655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034439
 protein coding gene Chr8:97963107-98001009 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031380
 protein coding gene Chr8:84682659-84715906 (-)
CAST/EiJ MGP_CASTEiJ_G0032960
 protein coding gene Chr8:93603453-93640740 (-)
CBA/J MGP_CBAJ_G0033604
 protein coding gene Chr8:101233010-101271981 (-)
DBA/2J MGP_DBA2J_G0033758
 protein coding gene Chr8:90325236-90356323 (-)
FVB/NJ MGP_FVBNJ_G0033705
 protein coding gene Chr8:89282228-89314507 (-)
LP/J MGP_LPJ_G0033850
 protein coding gene Chr8:94655666-94688080 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033747
 protein coding gene Chr8:103566087-103599907 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034457
 protein coding gene Chr8:93473497-93508289 (-)
PWK/PhJ MGP_PWKPhJ_G0032662
 protein coding gene Chr8:89668477-89702537 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032499
 protein coding gene Chr8:92319953-92357053 (-)
WSB/EiJ MGP_WSBEiJ_G0033072
 protein coding gene Chr8:93912330-93945677 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES1, carboxylesterase 1
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833337 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CES1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased blood lipids, improved glucose tolerance, and increased energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    110
  • cDNA Data
    106
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104158 NCBI Gene Model | MGI Sequence Detail 31733 C57BL/6J ±  kb
    transcript NM_053200 RefSeq | MGI Sequence Detail 1966 C57BL/6  
    polypeptide Q8VCT4 UniProt | EBI | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 106
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:113779 Mori M, et al., cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. FEBS Lett. 1999 Sep 10;458(1):17-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory