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Ehmt2 Gene Detail
Summary
  • Symbol
    Ehmt2
  • Name
    euchromatic histone lysine N-methyltransferase 2
  • Synonyms
    Bat8, D17Ertd710e, G9a, KMT1C, NG36
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148922
    NCBI Gene: 110147
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35117445-35133028 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148922
 protein coding gene Chr17:35117427-35133049 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023597
 protein coding gene Chr17:35016221-35037519 (+)
A/J MGP_AJ_G0023559
 protein coding gene Chr17:33872158-33888254 (+)
AKR/J MGP_AKRJ_G0023525
 protein coding gene Chr17:34332474-34350602 (+)
BALB/cJ MGP_BALBcJ_G0023564
 protein coding gene Chr17:33998881-34016054 (+)
C3H/HeJ MGP_C3HHeJ_G0023324
 protein coding gene Chr17:34729341-34746428 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024004
 protein coding gene Chr17:36353087-36370932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021483
 protein coding gene Chr17:31634656-31652997 (+)
CAST/EiJ MGP_CASTEiJ_G0022822
 protein coding gene Chr17:34724372-34742550 (+)
CBA/J MGP_CBAJ_G0023302
 protein coding gene Chr17:37860320-37876856 (+)
DBA/2J MGP_DBA2J_G0023430
 protein coding gene Chr17:33185594-33203548 (+)
FVB/NJ MGP_FVBNJ_G0023397
 protein coding gene Chr17:33017128-33034544 (+)
LP/J MGP_LPJ_G0023507
 protein coding gene Chr17:35337476-35365725 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023420
 protein coding gene Chr17:36798998-36815515 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024046
 protein coding gene Chr17:34559069-34575439 (+)
PWK/PhJ MGP_PWKPhJ_G0022571
 protein coding gene Chr17:32013420-32030324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022388
 protein coding gene Chr17:32562307-32580061 (+)
WSB/EiJ MGP_WSBEiJ_G0022884
 protein coding gene Chr17:34668864-34690038 (+)



Homology
more
  • Human Ortholog
    EHMT2, euchromatic histone lysine methyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EHMT2, euchromatic histone lysine methyltransferase 2
  • Synonyms
    BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
  • Links
    NCBI Gene ID: 10919
    neXtProt AC: NX_Q96KQ7
    UniProt: Q96KQ7

  • Chr Location
    6p21.33; chr6:31879759-31897698 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EHMT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 8 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E9.5-E12.5. Mutant embryos are developmentally delayed. Conditional deletion in germ cells results in infertility and arrest of meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    152
  • cDNA Data
    284
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013787 Ensembl Gene Model | MGI Sequence Detail 15584 C57BL/6J ±  kb
    transcript ENSMUST00000013931 Ensembl | MGI Sequence Detail 4026 Not Applicable  
    polypeptide ENSMUSP00000013931 Ensembl | MGI Sequence Detail 1263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 299
      Genomic 6
      cDNA 284
      Primer pair 7
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1513, MGI:1289297, MGI:1925626, MGI:88132
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 41
      Gene Ontology 31
      Phenotypes 67
    • Earliest
      J:15971 Gasser DL, et al., P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci [see comments]. Immunogenetics. 1994;39(1):48-55
    • Latest
      J:354236 Wada S, et al., The histone H3K9 methyltransferase G9a regulates tendon formation during development. Sci Rep. 2024 Sep 5;14(1):20771
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory