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Dock2 Gene Detail
Summary
  • Symbol
    Dock2
  • Name
    dedicator of cyto-kinesis 2
  • Synonyms
    CED-5, Hch, MBC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149010
    NCBI Gene: 94176
  • Alliance
    gene page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:34176815-34674719 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.68 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11834 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149010
 protein coding gene Chr11:34176815-34674732 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018151
 protein coding gene Chr11:32558581-33136401 (-)
A/J MGP_AJ_G0018124
 protein coding gene Chr11:31335200-31898672 (-)
AKR/J MGP_AKRJ_G0018088
 protein coding gene Chr11:32298849-32860281 (-)
BALB/cJ MGP_BALBcJ_G0018093
 protein coding gene Chr11:31507600-32067248 (-)
C3H/HeJ MGP_C3HHeJ_G0017906
 protein coding gene Chr11:32250716-32817715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018547
 protein coding gene Chr11:33598540-34172709 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016202
 protein coding gene Chr11:29822525-30381290 (-)
CAST/EiJ MGP_CASTEiJ_G0017470
 protein coding gene Chr11:32362196-32809626 (-)
CBA/J MGP_CBAJ_G0017879
 protein coding gene Chr11:35263855-35862099 (-)
DBA/2J MGP_DBA2J_G0017989
 protein coding gene Chr11:31095222-31652369 (-)
FVB/NJ MGP_FVBNJ_G0017983
 protein coding gene Chr11:30926477-31486850 (-)
LP/J MGP_LPJ_G0018061
 protein coding gene Chr11:32825491-33388233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018007
 protein coding gene Chr11:36158113-36603304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018586
 protein coding gene Chr11:32456733-32908063 (-)
PWK/PhJ MGP_PWKPhJ_G0017251
 protein coding gene Chr11:31287718-31728238 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017043
 protein coding gene Chr11:32192858-32664057 (-)
WSB/EiJ MGP_WSBEiJ_G0017519
 protein coding gene Chr11:32094722-32662324 (-)



Homology
more
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
  • Synonyms
    IMD40
  • Links
    NCBI Gene ID: 1794
    neXtProt AC: NX_Q92608
    UniProt: Q92608

  • Chr Location
    5q35.1; chr5:169637268-170083382 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DOCK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 21 alleles in 22 genetic backgrounds
    45 phenotypes from multigenic genotypes
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    32
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020143 Ensembl Gene Model | MGI Sequence Detail 497905 C57BL/6J ±  kb
    transcript ENSMUST00000093193 Ensembl | MGI Sequence Detail 6409 Not Applicable  
    polypeptide ENSMUSP00000090884 Ensembl | MGI Sequence Detail 1828 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144253, MGI:2144499
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 78
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357742 Churchhouse AMD, et al., Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated colorectal cancer via immune dysfunction and IFNgamma induction of IDO1 expression. Oncogene. 2024 Oct;43(42):3094-3107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory