Tle6 MGI Mouse Gene Detail - MGI:2149593 - transducin-like enhancer of split 6

Symbol

Tle6
Name

transducin-like enhancer of split 6
Synonyms

1810057E06Rik, Grg6

Feature Type

protein coding gene
IDs

MGI:2149593
NCBI Gene: 114606
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:81426738-81436907 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

290 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149593	protein coding gene	Chr10:81426738-81437021 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017567	protein coding gene	Chr10:82322727-82337343 (-)
A/J	MGP_AJ_G0017545	protein coding gene	Chr10:79397990-79408156 (-)
AKR/J	MGP_AKRJ_G0017506	protein coding gene	Chr10:81573419-81583590 (-)
BALB/cJ	MGP_BALBcJ_G0017507	protein coding gene	Chr10:79622936-79633167 (-)
C3H/HeJ	MGP_C3HHeJ_G0017330	protein coding gene	Chr10:81682745-81692874 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017961	protein coding gene	Chr10:85145144-85157056 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015650	protein coding gene	Chr10:75593885-75604072 (-)
CAST/EiJ	MGP_CASTEiJ_G0016897	protein coding gene	Chr10:81927125-81937286 (-)
CBA/J	MGP_CBAJ_G0017302	protein coding gene	Chr10:88489220-88501615 (-)
DBA/2J	MGP_DBA2J_G0017408	protein coding gene	Chr10:78602258-78612539 (-)
FVB/NJ	MGP_FVBNJ_G0017402	protein coding gene	Chr10:77871366-77882164 (-)
LP/J	MGP_LPJ_G0017479	protein coding gene	Chr10:82774861-82791477 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017428	protein coding gene	Chr10:90310247-90320407 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018002	protein coding gene	Chr10:81593965-81604195 (-)
PWK/PhJ	MGP_PWKPhJ_G0016678	protein coding gene	Chr10:78508819-78519237 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016468	protein coding gene	Chr10:80539005-80549173 (-)
WSB/EiJ	MGP_WSBEiJ_G0016957	protein coding gene	Chr10:81640811-81651997 (-)

Human Ortholog

TLE6, TLE family member 6, subcortical maternal complex member

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLE6, TLE family member 6, subcortical maternal complex member
Synonyms

GRG6, OZEMA15, PREMBL
Links

HGNC:30788

NCBI Gene ID: 79816

neXtProt AC: NX_Q9H808

UniProt: Q9H808
Chr Location

19p13.3; chr19:2977401-2995179 (+) GRCh38

MGI Vertebrate Homology

Tle6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TLE6
Gene Tree

Tle6

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

25
Targeted

5
Transgenic

1
Genomic Mutations

1 involving Tle6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

83
cDNA Data

55
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

93
RefSeq

38
UniProt

6
CCDS

CCDS24064.1, CCDS83737.1

Ensembl

ENSMUSG00000034758 (Evidence)
NCBI Gene

114606

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034758	Ensembl Gene Model \| MGI Sequence Detail	10170	C57BL/6J	± kb
transcript	ENSMUST00000072020	Ensembl \| MGI Sequence Detail	2015	Not Applicable
polypeptide	ENSMUSP00000071905	Ensembl \| MGI Sequence Detail	581	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016376 transducin-like enhancer protein 6

(term hierarchy)
PDB

8H93, 8H94, 8H95, 8H96
InterPro Domains

IPR009146 Groucho/transducin-like enhancer

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 59

cDNA 55

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1917049

Summaries

All 66

Developmental Gene Expression 17

Gene Ontology 11

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887

TSS for Tle6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98658	Chr10:81436697-81436715 (-)	201 bp
Tssr98657	Chr10:81433435-81433463 (-)	3,458 bp
Tssr98656	Chr10:81433164-81433201 (-)	3,724 bp
Tssr3289	Chr10:81432533-81432548 (-)	4,366 bp
Tssr98655	Chr10:81432321-81432325 (-)	4,584 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24