Impa2 MGI Mouse Gene Detail - MGI:2149728 - inositol monophosphatase 2

Symbol

Impa2
Name

inositol monophosphatase 2
Synonyms

2210415D20Rik, inositol (myo)-1(or 4)-monophosphatase 2

Feature Type

protein coding gene
IDs

MGI:2149728
NCBI Gene: 114663
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:67422246-67454375 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 39.92 cM
Mapping Data

2 experiments

SNPs within 2kb

1108 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149728	protein coding gene	Chr18:67422246-67455542 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024521	protein coding gene	Chr18:67564913-67594715 (+)
A/J	MGP_AJ_G0024488	protein coding gene	Chr18:64611087-64642455 (+)
AKR/J	MGP_AKRJ_G0024458	protein coding gene	Chr18:66512910-66542800 (+)
BALB/cJ	MGP_BALBcJ_G0024487	protein coding gene	Chr18:64783062-64813348 (+)
C3H/HeJ	MGP_C3HHeJ_G0024255	protein coding gene	Chr18:66668878-66699300 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024934	protein coding gene	Chr18:69361955-69394204 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022365	protein coding gene	Chr18:63992331-64023490 (+)
CAST/EiJ	MGP_CASTEiJ_G0023728	protein coding gene	Chr18:66662282-66695567 (+)
CBA/J	MGP_CBAJ_G0024225	protein coding gene	Chr18:71739576-71772558 (+)
DBA/2J	MGP_DBA2J_G0024355	protein coding gene	Chr18:64268899-64298769 (+)
FVB/NJ	MGP_FVBNJ_G0024321	protein coding gene	Chr18:63640179-63670882 (+)
LP/J	MGP_LPJ_G0024439	protein coding gene	Chr18:67425000-67456712 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024350	protein coding gene	Chr18:73022253-73052993 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024981	protein coding gene	Chr18:66674828-66706403 (+)
PWK/PhJ	MGP_PWKPhJ_G0023471	protein coding gene	Chr18:64541645-64574602 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023276	protein coding gene	Chr18:66837041-66868339 (+)
WSB/EiJ	MGP_WSBEiJ_G0023792	protein coding gene	Chr18:66562575-66593635 (+)

Human Ortholog

IMPA2, inositol monophosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IMPA2, inositol monophosphatase 2
Links

HGNC:6051

NCBI Gene ID: 3613

neXtProt AC: NX_O14732

UniProt: O14732
Chr Location

18p11.21; chr18:11981025-12030877 (+) GRCh38

MGI Vertebrate Homology

Impa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IMPA2
Gene Tree

Impa2

Diseases

2 with human IMPA2 associations

				Human Disease	Mouse Models
				bipolar disorder IDs bipolar disorder DOID:3312 DOID:3311 DOID:9554 DOID:9555 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (ENU)

1
Endonuclease-mediated

2
Gene trapped

33
Targeted

4
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null gene trap mutation do not exhibit an overt mutant phenotype. Male mice homozygous for a knock-out alle exhibit increased prepulse inhibition.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

846
Tissues

123
cDNA Data

20
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase impa2

ZFIN impa2

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All Sequences

50
RefSeq

3
UniProt

4
CCDS

CCDS29320.1

Ensembl

ENSMUSG00000024525 (Evidence)
NCBI Gene

114663

			Length	Strain/Species	Flank
genomic	114663	NCBI Gene Model \| MGI Sequence Detail	32130	C57BL/6J	± kb
transcript	NM_053261	RefSeq \| MGI Sequence Detail	1737	C57BL/6
polypeptide	Q91UZ5	UniProt \| EBI \| MGI Sequence Detail	290	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009018 inositol monophosphatase 2

(term hierarchy)
EC

3.1.3.25
InterPro Domains

IPR033942 Inositol monophosphatase

IPR020550 Inositol monophosphatase, conserved site

IPR000760 Inositol monophosphatase-like

IPR020552 Inositol monophosphatase, lithium-sensitive

IPR020583 Inositol monophosphatase, metal-binding site

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All nucleic 22

cDNA 20

Primer pair 2

Microarray probesets 3

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MGI:1917400, MGI:2147214, MGI:2147360

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:250420 Ohnishi T, et al., Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. J Biol Chem. 2014 Apr 11;289(15):10785-96

TSS for Impa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151728	Chr18:67420893-67420896 (+)	-1,351 bp
Tssr151729	Chr18:67422275-67422295 (+)	39 bp
Tssr151730	Chr18:67422297-67422304 (+)	55 bp
Tssr151731	Chr18:67422305-67422328 (+)	71 bp
Tssr151732	Chr18:67441611-67441633 (+)	19,376 bp
Tssr151733	Chr18:67441639-67441668 (+)	19,408 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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