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Nans Gene Detail
Summary
  • Symbol
    Nans
  • Name
    N-acetylneuraminic acid synthase (sialic acid synthase)
  • Synonyms
    4632418E04Rik, N-acetylneuraminic acid phosphate synthase, Sas
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149820
    NCBI Gene: 94181
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46489319-46503439 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.83 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    547 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149820
 protein coding gene Chr4:46489248-46503632 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028259
 protein coding gene Chr4:44809152-44823538 (+)
A/J MGP_AJ_G0028218
 protein coding gene Chr4:43164387-43178774 (+)
AKR/J MGP_AKRJ_G0028168
 protein coding gene Chr4:44216286-44230670 (+)
BALB/cJ MGP_BALBcJ_G0028238
 protein coding gene Chr4:43266304-43280686 (+)
C3H/HeJ MGP_C3HHeJ_G0027959
 protein coding gene Chr4:44826104-44841029 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028679
 protein coding gene Chr4:46462589-46478318 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025988
 protein coding gene Chr4:40543806-40558965 (+)
CAST/EiJ MGP_CASTEiJ_G0027398
 protein coding gene Chr4:44380812-44397514 (+)
CBA/J MGP_CBAJ_G0027925
 protein coding gene Chr4:47945370-47959709 (+)
DBA/2J MGP_DBA2J_G0028075
 protein coding gene Chr4:43054199-43068824 (+)
FVB/NJ MGP_FVBNJ_G0028042
 protein coding gene Chr4:42303465-42317848 (+)
LP/J MGP_LPJ_G0028174
 protein coding gene Chr4:44860197-44874647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028066
 protein coding gene Chr4:51017466-51032197 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028714
 protein coding gene Chr4:44437474-44452899 (+)
PWK/PhJ MGP_PWKPhJ_G0027123
 protein coding gene Chr4:43158776-43173371 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026951
 protein coding gene Chr4:43941406-43958004 (+)
WSB/EiJ MGP_WSBEiJ_G0027476
 protein coding gene Chr4:44349875-44364269 (+)



Homology
more
  • Human Ortholog
    NANS, N-acetylneuraminate synthase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NANS, N-acetylneuraminate synthase
  • Synonyms
    HEL-S-100, SAS, SEMDCG, SEMDG
  • Links
    NCBI Gene ID: 54187
    neXtProt AC: NX_Q9NR45
    UniProt: Q9NR45

  • Chr Location
    9q22.33; chr9:98056732-98083077 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NANS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    128
  • cDNA Data
    112
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94181 NCBI Gene Model | MGI Sequence Detail 14121 C57BL/6J ±  kb
    transcript NM_001419303 RefSeq | MGI Sequence Detail 1949 C57BL/6  
    polypeptide Q99J77 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 113
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918061, MGI:2140633
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:63317 Nakata D, et al., Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity. Biochem Biophys Res Commun. 2000 Jul 5;273(2):642-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory