Hsd17b11 MGI Mouse Gene Detail - MGI:2149821 - hydroxysteroid (17-beta) dehydrogenase 11

Symbol

Hsd17b11
Name

hydroxysteroid (17-beta) dehydrogenase 11
Synonyms

17beta-HSD11, Dhrs8, Pan1b, retSDR2

Feature Type

protein coding gene
IDs

MGI:2149821
NCBI Gene: 114664
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:104137631-104169662 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 50.52 cM, cytoband E4
Mapping Data

3 experiments

SNPs within 2kb

969 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149821	protein coding gene	Chr5:104137628-104169785 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029806	protein coding gene	Chr5:105651164-105686177 (-)
A/J	MGP_AJ_G0029770	protein coding gene	Chr5:101677437-101710973 (-)
AKR/J	MGP_AKRJ_G0029718	protein coding gene	Chr5:104960686-104995476 (-)
BALB/cJ	MGP_BALBcJ_G0029782	protein coding gene	Chr5:102739058-102771635 (-)
C3H/HeJ	MGP_C3HHeJ_G0029505	protein coding gene	Chr5:105364993-105401777 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030237	protein coding gene	Chr5:109963629-110002187 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027472	protein coding gene	Chr5:96817077-96849718 (-)
CAST/EiJ	MGP_CASTEiJ_G0028916	protein coding gene	Chr5:104074104-104110928 (-)
CBA/J	MGP_CBAJ_G0029475	protein coding gene	Chr5:113797354-113835385 (-)
DBA/2J	MGP_DBA2J_G0029619	protein coding gene	Chr5:101868364-101901319 (-)
FVB/NJ	MGP_FVBNJ_G0029578	protein coding gene	Chr5:100663010-100694383 (-)
LP/J	MGP_LPJ_G0029707	protein coding gene	Chr5:106219017-106252701 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029607	protein coding gene	Chr5:118735821-118769481 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030270	protein coding gene	Chr5:104496324-104534298 (-)
PWK/PhJ	MGP_PWKPhJ_G0028634	protein coding gene	Chr5:100326571-100362203 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028469	protein coding gene	Chr5:102153364-102185406 (-)
WSB/EiJ	MGP_WSBEiJ_G0028994	protein coding gene	Chr5:104870039-104906650 (-)

Human Ortholog

HSD17B11, hydroxysteroid 17-beta dehydrogenase 11

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSD17B11, hydroxysteroid 17-beta dehydrogenase 11
Synonyms

17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2
Links

HGNC:22960

NCBI Gene ID: 51170

neXtProt AC: NX_Q8NBQ5

UniProt: Q8NBQ5
Chr Location

4q22.1; chr4:87336515-87391188 (-) GRCh38

MGI Vertebrate Homology

Hsd17b11 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HSD17B11
Gene Tree

Hsd17b11

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

3
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Hsd17b11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibit an increased mean serum IgG2a response to ovalbumin challenge and an increased mean percentage of immature B cells in bone marrow.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

22
cDNA Data

62
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsd17b11

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS19481.1

Ensembl

ENSMUSG00000029311 (Evidence)
NCBI Gene

114664

			Length	Strain/Species	Flank
genomic	114664	NCBI Gene Model \| MGI Sequence Detail	32032	C57BL/6J	± kb
transcript	NM_053262	RefSeq \| MGI Sequence Detail	1699	C57BL/6
polypeptide	Q9EQ06	UniProt \| EBI \| MGI Sequence Detail	298	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008775 estradiol 17-beta-dehydrogenase 11

(term hierarchy)
EC

1.1.1.62
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

Q9EQ06 1 site, 1 O-linked glycan (1 site)

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All nucleic 63

cDNA 63

Microarray probesets 5

Summaries

All 51

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hsd17b11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52188	Chr5:104170056-104170076 (-)	-404 bp
Tssr52187	Chr5:104169997-104170052 (-)	-363 bp
Tssr52186	Chr5:104169980-104169995 (-)	-326 bp
Tssr52185	Chr5:104169814-104169833 (-)	-162 bp
Tssr52184	Chr5:104169794-104169811 (-)	-141 bp
Tssr52183	Chr5:104169665-104169731 (-)	-36 bp
Tssr52182	Chr5:104169645-104169662 (-)	8 bp
Tssr52181	Chr5:104166297-104166300 (-)	3,363 bp
Tssr52180	Chr5:104166262-104166272 (-)	3,395 bp
Tssr52179	Chr5:104165631-104165657 (-)	4,018 bp
Tssr52178	Chr5:104138104-104138109 (-)	31,555 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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