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Hycc1 Gene Detail
Summary
  • Symbol
    Hycc1
  • Name
    hyccin PI4KA lipid kinase complex subunit 1
  • Synonyms
    Fam126a, hyccin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149839
    NCBI Gene: 84652
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24120274-24235688 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 10.53 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3481 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149839
 protein coding gene Chr5:24120274-24235694 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029334
 protein coding gene Chr5:21610895-21738722 (-)
A/J MGP_AJ_G0029300
 protein coding gene Chr5:20880906-20998129 (-)
AKR/J MGP_AKRJ_G0029251
 protein coding gene Chr5:21729371-21853918 (-)
BALB/cJ MGP_BALBcJ_G0029311
 protein coding gene Chr5:21403174-21519122 (-)
C3H/HeJ MGP_C3HHeJ_G0029031
 protein coding gene Chr5:21825021-21967483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029764
 protein coding gene Chr5:23086800-23212118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027002
 protein coding gene Chr5:18836119-18957002 (-)
CAST/EiJ MGP_CASTEiJ_G0028443
 protein coding gene Chr5:21005755-21137857 (-)
CBA/J MGP_CBAJ_G0028998
 protein coding gene Chr5:23430685-23574502 (-)
DBA/2J MGP_DBA2J_G0029149
 protein coding gene Chr5:21166672-21297115 (-)
FVB/NJ MGP_FVBNJ_G0029107
 protein coding gene Chr5:20558146-20672727 (-)
LP/J MGP_LPJ_G0029233
 protein coding gene Chr5:22004825-22142017 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029136
 protein coding gene Chr5:24605443-24742987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029798
 protein coding gene Chr5:21350987-21496559 (-)
PWK/PhJ MGP_PWKPhJ_G0028165
 protein coding gene Chr5:20152846-20374333 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027998
 protein coding gene Chr5:20721900-20847425 (-)
WSB/EiJ MGP_WSBEiJ_G0028523
 protein coding gene Chr5:21430342-21556805 (-)



Homology
more
  • Human Ortholog
    HYCC1, hyccin PI4KA lipid kinase complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYCC1, hyccin PI4KA lipid kinase complex subunit 1
  • Synonyms
    DRCTNNB1A, FAM126A, HCC, HLD5
  • Links
    NCBI Gene ID: 84668
    neXtProt AC: NX_Q9BYI3
    UniProt: Q9BYI3

  • Chr Location
    7p15.3; chr7:22889371-23014130 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HYCC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation not exhibit an obvious abnormal phenotype or specific defects in myelination as evaluated by light and electron microscopy analysis, unlike human patients.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    3
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028995 Ensembl Gene Model | MGI Sequence Detail 115415 C57BL/6J ±  kb
    transcript ENSMUST00000030849 Ensembl | MGI Sequence Detail 5659 Not Applicable  
    polypeptide ENSMUSP00000030849 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:7328924
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory