Dbsty3 QTL Detail

Summary

• Symbol
  Dbsty3
• Name
  diabesity 3

• Feature Type
  QTL
• IDs
  MGI:2149845
  NCBI Gene: 114684
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr12:100532075-100532224 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 50.87 cM (cM position of peak correlated region/marker)
• QTL Archive
  Reifsnyder1 download
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 2 alleles in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  114684

References

• Summaries
  All 5

  Phenotypes 2
• Earliest
  J:65256 Reifsnyder PC, et al., Maternal environment and genotype interact to establish diabesity in mice. Genome Res. 2000 Oct;10(10):1568-78
• Latest
  J:91835 Kaput J, et al., Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics. 2004 Aug 11;18(3):316-24

Candidate Genes for Dbsty3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Gsc	Chr12:104437468-104439495 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 12, Gsc (52 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Dbsty3 (48 cM) and Mob3 (53 cM) map near candidate gene Gsc.