Dbsty4 QTL Detail

Summary

• Symbol
  Dbsty4
• Name
  diabesity 4

• Feature Type
  QTL
• IDs
  MGI:2149846
  NCBI Gene: 114685
• Candidate Genes
  5 Genes

Location &
Maps

• Sequence Map
  Chr15:87349271-87349416 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 41.96 cM (cM position of peak correlated region/marker)
• QTL Archive
  Reifsnyder1 download
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  114685

References

• Summaries
  All 6

  Phenotypes 2
• Earliest
  J:65256 Reifsnyder PC, et al., Maternal environment and genotype interact to establish diabesity in mice. Genome Res. 2000 Oct;10(10):1568-78
• Latest
  J:137428 Schmidt C, et al., A meta-analysis of QTL for diabetes-related traits in rodents. Physiol Genomics. 2008 Jun 12;34(1):42-53

Candidate Genes for Dbsty4:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Desi1	Chr15:81876724-81900364 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Gpt	Chr15:76580926-76583875 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
H1f0	Chr15:78912650-78914704 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Npr3	Chr15:11839982-11907287 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Tef	Chr15:81686874-81711064 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.