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Gopc Gene Detail
Summary
  • Symbol
    Gopc
  • Name
    golgi associated PDZ and coiled-coil motif containing
  • Synonyms
    2210402P09Rik, GOPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149946
    NCBI Gene: 94221
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:52213120-52258220 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 26.54 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149946
 protein coding gene Chr10:52211946-52258220 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017223
 protein coding gene Chr10:51489959-51539236 (-)
A/J MGP_AJ_G0017199
 protein coding gene Chr10:49979285-50025200 (-)
AKR/J MGP_AKRJ_G0017158
 protein coding gene Chr10:50928819-50977193 (-)
BALB/cJ MGP_BALBcJ_G0017160
 protein coding gene Chr10:50077688-50125628 (-)
C3H/HeJ MGP_C3HHeJ_G0016982
 protein coding gene Chr10:51183351-51233002 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017619
 protein coding gene Chr10:53124926-53174445 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015313
 protein coding gene Chr10:47201007-47245703 (-)
CAST/EiJ MGP_CASTEiJ_G0016556
 protein coding gene Chr10:51313138-51355785 (-)
CBA/J MGP_CBAJ_G0016955
 protein coding gene Chr10:55388687-55444061 (-)
DBA/2J MGP_DBA2J_G0017060
 protein coding gene Chr10:49391466-49436301 (-)
FVB/NJ MGP_FVBNJ_G0017054
 protein coding gene Chr10:48741001-48786071 (-)
LP/J MGP_LPJ_G0017135
 protein coding gene Chr10:51554662-51618153 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017083
 protein coding gene Chr10:57314528-57364766 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017654
 protein coding gene Chr10:50869051-50916792 (-)
PWK/PhJ MGP_PWKPhJ_G0016337
 protein coding gene Chr10:49186802-49297947 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016122
 protein coding gene Chr10:50485680-50529722 (-)
WSB/EiJ MGP_WSBEiJ_G0016621
 protein coding gene Chr10:51086081-51137263 (-)



Homology
more
  • Human Ortholog
    GOPC, golgi associated PDZ and coiled-coil motif containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOPC, golgi associated PDZ and coiled-coil motif containing
  • Synonyms
    CAL, dJ94G16.2, FIG, GOPC1, PIST
  • Links
    NCBI Gene ID: 57120
    neXtProt AC: NX_Q9HD26
    UniProt: Q9HD26

  • Chr Location
    6q22.1; chr6:117560269-117602542 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gopc mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show male sterility with globozoospermia characterized by a complete lack of acrosomes due to failure of vesicle transport from the Golgi apparatus, a malformed sperm nucleus, and abnormal mitochondrial arrangement in the mitochondrial sheath of mutant spermatozoa.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    37
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94221 NCBI Gene Model | MGI Sequence Detail 45101 C57BL/6J ±  kb
    transcript NM_001199272 RefSeq | MGI Sequence Detail 4319 C57BL/6  
    polypeptide Q8BH60 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1913757, MGI:2143681
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory