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Olig3 Gene Detail
Summary
  • Symbol
    Olig3
  • Name
    oligodendrocyte transcription factor 3
  • Synonyms
    Bhlhb7, bHLHe20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149955
    NCBI Gene: 94222
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19232287-19234352 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 8.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149955
 protein coding gene Chr10:19232281-19234352 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017044
 protein coding gene Chr10:17072703-17074753 (+)
A/J MGP_AJ_G0017022
 protein coding gene Chr10:16426737-16428801 (+)
AKR/J MGP_AKRJ_G0016986
 protein coding gene Chr10:16692836-16694886 (+)
BALB/cJ MGP_BALBcJ_G0016980
 protein coding gene Chr10:16487430-16489478 (+)
C3H/HeJ MGP_C3HHeJ_G0016805
 protein coding gene Chr10:17019229-17021291 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017442
 protein coding gene Chr10:17498826-17500872 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015147
 protein coding gene Chr10:15439730-15441792 (+)
CAST/EiJ MGP_CASTEiJ_G0016387
 protein coding gene Chr10:16886744-16888806 (+)
CBA/J MGP_CBAJ_G0016777
 protein coding gene Chr10:18289675-18291741 (+)
DBA/2J MGP_DBA2J_G0016885
 protein coding gene Chr10:16307737-16309783 (+)
FVB/NJ MGP_FVBNJ_G0016880
 protein coding gene Chr10:16068246-16070624 (+)
LP/J MGP_LPJ_G0016960
 protein coding gene Chr10:16884791-16886849 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016910
 protein coding gene Chr10:18552563-18554606 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017480
 protein coding gene Chr10:16681084-16683130 (+)
PWK/PhJ MGP_PWKPhJ_G0016172
 protein coding gene Chr10:16168524-16170663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015955
 protein coding gene Chr10:16840046-16842087 (+)
WSB/EiJ MGP_WSBEiJ_G0016449
 protein coding gene Chr10:16783216-16785251 (+)



Homology
more
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
  • Synonyms
    Bhlhb7, bHLHe20
  • Links
    NCBI Gene ID: 167826
    neXtProt AC: NX_Q7RTU3
    UniProt: Q7RTU3

  • Chr Location
    6q23.3; chr6:137492199-137494394 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit impaired development of class A neurons in the dorsal spinal cord, the alar plate, with reduced numbers of dI1 neurons and misspecified dI2 and dI3 neurons that assume the identity of class B neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    119
  • cDNA Data
    7
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94222 NCBI Gene Model | MGI Sequence Detail 2066 C57BL/6J ±  kb
    transcript NM_053008 RefSeq | MGI Sequence Detail 2066 C57BL/6  
    polypeptide Q6PFG8 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011633 oligodendrocyte transcription factor 3
      (term hierarchy)
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032659 Oligodendrocyte transcription factor 3, basic helix-loop-helix domain
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 7
      Primer pair 2
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 55
      Gene Ontology 7
      Phenotypes 36
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:344557 Hall ET, et al., Cytoneme signaling provides essential contributions to mammalian tissue patterning. Cell. 2024 Jan 18;187(2):276-293.e23
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory