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Spred1 Gene Detail
Summary
  • Symbol
    Spred1
  • Name
    sprouty protein with EVH-1 domain 1, related sequence
  • Synonyms
    5730461F13Rik, Spred-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150016
    NCBI Gene: 114715
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:116951855-117012760 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.03 cM, cytoband E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150016
 protein coding gene Chr2:116951576-117012760 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026308
 protein coding gene Chr2:119752537-119816171 (+)
A/J MGP_AJ_G0026269
 protein coding gene Chr2:114882967-114943916 (+)
AKR/J MGP_AKRJ_G0026248
 protein coding gene Chr2:118094632-118161062 (+)
BALB/cJ MGP_BALBcJ_G0026282
 protein coding gene Chr2:115137955-115199513 (+)
C3H/HeJ MGP_C3HHeJ_G0026028
 protein coding gene Chr2:118521434-118589026 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026729
 protein coding gene Chr2:123692623-123755701 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024109
 protein coding gene Chr2:109960115-110022905 (+)
CAST/EiJ MGP_CASTEiJ_G0025490
 protein coding gene Chr2:118843947-118913751 (+)
CBA/J MGP_CBAJ_G0026004
 protein coding gene Chr2:128047854-128116487 (+)
DBA/2J MGP_DBA2J_G0026143
 protein coding gene Chr2:114312042-114373292 (+)
FVB/NJ MGP_FVBNJ_G0026105
 protein coding gene Chr2:113144708-113205315 (+)
LP/J MGP_LPJ_G0026244
 protein coding gene Chr2:120072639-120135303 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026124
 protein coding gene Chr2:132465837-132545284 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026784
 protein coding gene Chr2:118201741-118263540 (+)
PWK/PhJ MGP_PWKPhJ_G0025226
 protein coding gene Chr2:113864488-113925802 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025025
 protein coding gene Chr2:117330204-117389007 (+)
WSB/EiJ MGP_WSBEiJ_G0025559
 protein coding gene Chr2:119023478-119087417 (+)



Homology
more
  • Human Ortholog
    SPRED1, sprouty related EVH1 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRED1, sprouty related EVH1 domain containing 1
  • Synonyms
    hSpred1, LGSS, NFLS, PPP1R147, spred-1
  • Links
    NCBI Gene ID: 161742
    neXtProt AC: NX_Q7Z699
    UniProt: Q7Z699

  • Chr Location
    15q14; chr15:38252836-38357249 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPRED1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased airway hyperresponsiveness, eosinophilia, a kinked tail, shortened face, impaired spatial learning and memory, and altered CNS transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    36
  • cDNA Data
    17
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027351 Ensembl Gene Model | MGI Sequence Detail 60906 C57BL/6J ±  kb
    transcript ENSMUST00000028829 Ensembl | MGI Sequence Detail 6016 Not Applicable  
    polypeptide ENSMUSP00000028829 Ensembl | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1917839, MGI:2139136, MGI:2139276
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory