Bw19 QTL Detail

Summary

• Symbol
  Bw19
• Name
  body weight QTL 19
• Synonyms
  QbwX

• Feature Type
  QTL
• IDs
  MGI:2150137
  NCBI Gene: 114813
• Candidate Genes
  4 Genes

Location &
Maps

• Sequence Map
  ChrX:46376920-52412327 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 24.88 cM (cM position of peak correlated region/marker)
• Mapping Data
  5 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  114813

References

• Summaries
  All 9

  Phenotypes 4
• Earliest
  J:45362 Rance KA, et al., Mapping quantitative trait loci for body weight on the X chromosome in mice. I. Analysis of a reciprocal F2 population. Genet Res. 1997 Oct;70(2):117-24
• Latest
  J:99479 Oliver F, et al., Regulatory variation at glypican-3 underlies a major growth QTL in mice. PLoS Biol. 2005 May;3(5):e135

Candidate Genes for Bw19:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Atp6ap1	ChrX:73340753-73348297 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome X, Atp6ap1 (29.8 cM), Flna (29.8 cM), and Gdi1 (29.8 cM) all show differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw19 (26.4 cM) and C10bw6 (32 cM) map near these candidate genes. Jarid1c (64 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Dob7 (59.5 cM) maps near Jarid1c.
Flna	ChrX:73267067-73293426 (-)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome X, Atp6ap1 (29.8 cM), Flna (29.8 cM), and Gdi1 (29.8 cM) all show differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw19 (26.4 cM) and C10bw6 (32 cM) map near these candidate genes. Jarid1c (64 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Dob7 (59.5 cM) maps near Jarid1c.
Gdi1	ChrX:73348618-73355473 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome X, Atp6ap1 (29.8 cM), Flna (29.8 cM), and Gdi1 (29.8 cM) all show differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw19 (26.4 cM) and C10bw6 (32 cM) map near these candidate genes. Jarid1c (64 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Dob7 (59.5 cM) maps near Jarid1c.
Kdm5c	ChrX:151016016-151057531 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome X, Atp6ap1 (29.8 cM), Flna (29.8 cM), and Gdi1 (29.8 cM) all show differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw19 (26.4 cM) and C10bw6 (32 cM) map near these candidate genes. Jarid1c (64 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Dob7 (59.5 cM) maps near Jarid1c.