Dcun1d1 MGI Mouse Gene Detail - MGI:2150386 - defective in cullin neddylation 1 domain containing 1

Symbol

Dcun1d1
Name

defective in cullin neddylation 1 domain containing 1
Synonyms

DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae), pTes3, Rp42, SCCRO, Tes3

Feature Type

protein coding gene
IDs

MGI:2150386
NCBI Gene: 114893
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:35946254-35991594 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 17.41 cM
Mapping Data

3 experiments

SNPs within 2kb

1041 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150386	protein coding gene	Chr3:35946254-35991626 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027152	protein coding gene	Chr3:33641565-33691354 (-)
A/J	MGP_AJ_G0027112	protein coding gene	Chr3:33024443-33065538 (-)
AKR/J	MGP_AKRJ_G0027081	protein coding gene	Chr3:33619695-33664082 (-)
BALB/cJ	MGP_BALBcJ_G0027124	protein coding gene	Chr3:32779726-32821633 (-)
C3H/HeJ	MGP_C3HHeJ_G0026867	protein coding gene	Chr3:33697179-33738678 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027570	protein coding gene	Chr3:35282569-35329810 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024931	protein coding gene	Chr3:30749163-30792867 (-)
CAST/EiJ	MGP_CASTEiJ_G0026320	protein coding gene	Chr3:33529201-33574541 (-)
CBA/J	MGP_CBAJ_G0026844	protein coding gene	Chr3:36220175-36265528 (-)
DBA/2J	MGP_DBA2J_G0026978	protein coding gene	Chr3:32497891-32539856 (-)
FVB/NJ	MGP_FVBNJ_G0026946	protein coding gene	Chr3:31938303-31981169 (-)
LP/J	MGP_LPJ_G0027090	protein coding gene	Chr3:34423614-34468765 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026966	protein coding gene	Chr3:38677123-38725321 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027629	protein coding gene	Chr3:33469135-33511506 (-)
PWK/PhJ	MGP_PWKPhJ_G0026053	protein coding gene	Chr3:32143343-32187093 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025865	protein coding gene	Chr3:32848244-32888642 (-)
WSB/EiJ	MGP_WSBEiJ_G0026394	protein coding gene	Chr3:33497615-33540598 (-)

Human Ortholog

DCUN1D1, defective in cullin neddylation 1 domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCUN1D1, defective in cullin neddylation 1 domain containing 1
Synonyms

DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3
Links

HGNC:18184

NCBI Gene ID: 54165

neXtProt AC: NX_Q96GG9

UniProt: Q96GG9
Chr Location

3q26.33; chr3:182938074-182985953 (-) GRCh38

MGI Vertebrate Homology

Dcun1d1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCUN1D1
Gene Tree

Dcun1d1

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Genomic Mutations

1 involving Dcun1d1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are runted with spleen and lymphoid hypoplasia and decreased mouse embryonic fibroblast proliferation. Males are infertile and exhibit abnormal spermiogenesis.

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All GO Annotations

20
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

50
cDNA Data

17
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DCUN1D1

Xenbase dcun1d1

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All Sequences

78
RefSeq

11
UniProt

1
CCDS

CCDS17306.1, CCDS57207.1

Ensembl

ENSMUSG00000027708 (Evidence)
NCBI Gene

114893

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027708	Ensembl Gene Model \| MGI Sequence Detail	45341	C57BL/6J	± kb
transcript	ENSMUST00000108182	Ensembl \| MGI Sequence Detail	4980	Not Applicable
polypeptide	ENSMUSP00000103817	Ensembl \| MGI Sequence Detail	259	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006330 DCN1-like protein 1

(term hierarchy)

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 8

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MGI:1858962, MGI:2140091

Summaries

All 44

Developmental Gene Expression 5

Diseases 1

Gene Ontology 3

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Dcun1d1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr861	Chr3:35991623-35991628 (-)	-32 bp
Tssr33011	Chr3:35991552-35991600 (-)	18 bp
Tssr860	Chr3:35991535-35991539 (-)	57 bp
Tssr33010	Chr3:35987420-35987436 (-)	4,166 bp
Tssr33009	Chr3:35987244-35987249 (-)	4,347 bp
Tssr33008	Chr3:35987200-35987226 (-)	4,381 bp
Tssr33007	Chr3:35987007-35987053 (-)	4,564 bp
Tssr33006	Chr3:35986985-35987003 (-)	4,600 bp
Tssr33005	Chr3:35986719-35986745 (-)	4,862 bp
Tssr33004	Chr3:35986661-35986681 (-)	4,923 bp
Tssr33003	Chr3:35979763-35979766 (-)	11,829 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24