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Fgfrl1 Gene Detail
Summary
  • Symbol
    Fgfrl1
  • Name
    fibroblast growth factor receptor-like 1
  • Synonyms
    FGFR5, FGFR5beta, FGFR5gamma, fibroblast growth factor receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150920
    NCBI Gene: 116701
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108842051-108854816 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.24 cM, cytoband E3-F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150920
 protein coding gene Chr5:108840248-108854816 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029864
 protein coding gene Chr5:110826878-110841415 (+)
A/J MGP_AJ_G0029828
 protein coding gene Chr5:106561910-106576482 (+)
AKR/J MGP_AKRJ_G0029773
 protein coding gene Chr5:109999276-110014026 (+)
BALB/cJ MGP_BALBcJ_G0029840
 protein coding gene Chr5:107702264-107717090 (+)
C3H/HeJ MGP_C3HHeJ_G0029562
 protein coding gene Chr5:110493441-110508993 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030294
 protein coding gene Chr5:115353749-115371567 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027528
 protein coding gene Chr5:101573589-101588063 (+)
CAST/EiJ MGP_CASTEiJ_G0028976
 protein coding gene Chr5:109384111-109401483 (+)
CBA/J MGP_CBAJ_G0029530
 protein coding gene Chr5:119244088-119263462 (+)
DBA/2J MGP_DBA2J_G0029676
 protein coding gene Chr5:106687965-106702715 (+)
FVB/NJ MGP_FVBNJ_G0029633
 protein coding gene Chr5:105417628-105432109 (+)
LP/J MGP_LPJ_G0029764
 protein coding gene Chr5:111413618-111432692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029665
 protein coding gene Chr5:124127460-124146002 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030328
 protein coding gene Chr5:109544251-109558789 (+)
PWK/PhJ MGP_PWKPhJ_G0028689
 protein coding gene Chr5:105509954-105552354 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028527
 protein coding gene Chr5:107079575-107094123 (+)
WSB/EiJ MGP_WSBEiJ_G0029049
 protein coding gene Chr5:109878048-109894073 (+)



Homology
more
  • Human Ortholog
    FGFRL1, fibroblast growth factor receptor like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGFRL1, fibroblast growth factor receptor like 1
  • Synonyms
    FGFR-5, FGFR5, FHFR
  • Links
    NCBI Gene ID: 53834
    neXtProt AC: NX_Q8N441
    UniProt: Q8N441

  • Chr Location
    4p16.3; chr4:1009936-1026898 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgfrl1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 4 alleles in 5 genetic backgrounds
    3 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show neonatal death due to respiratory distress, a malformed diaphragm, and lack of metanephric kidneys. Homozygotes for a different null allele show both fetal and neonatal death, a similar diaphragm defect, as well as cardiac and skeletal defects, and fetal anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1367
  • Tissues
    169
  • cDNA Data
    52
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116701 NCBI Gene Model | MGI Sequence Detail 12766 C57BL/6J ±  kb
    transcript NM_054071 RefSeq | MGI Sequence Detail 2639 C57BL/6  
    polypeptide Q91V87 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 54
      Primer pair 3
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory