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Lsm10 Gene Detail
Summary
  • Symbol
    Lsm10
  • Name
    U7 snRNP-specific Sm-like protein LSM10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151045
    NCBI Gene: 116748
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125990416-125992377 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 59.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151045
 protein coding gene Chr4:125990350-125992377 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028770
 protein coding gene Chr4:127749790-127751751 (+)
A/J MGP_AJ_G0028729
 protein coding gene Chr4:122713371-122715332 (+)
AKR/J MGP_AKRJ_G0028682
 protein coding gene Chr4:126099685-126101646 (+)
BALB/cJ MGP_BALBcJ_G0028752
 protein coding gene Chr4:123298630-123300590 (+)
C3H/HeJ MGP_C3HHeJ_G0028466
 protein coding gene Chr4:126147552-126149512 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029194
 protein coding gene Chr4:132628847-132630808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026467
 protein coding gene Chr4:115869992-115871967 (+)
CAST/EiJ MGP_CASTEiJ_G0027899
 protein coding gene Chr4:124266410-124268349 (+)
CBA/J MGP_CBAJ_G0028432
 protein coding gene Chr4:135845281-135847241 (+)
DBA/2J MGP_DBA2J_G0028581
 protein coding gene Chr4:123181582-123183542 (+)
FVB/NJ MGP_FVBNJ_G0028548
 protein coding gene Chr4:121830182-121832142 (+)
LP/J MGP_LPJ_G0028682
 protein coding gene Chr4:128036713-128038674 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028574
 protein coding gene Chr4:140874437-140876397 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029232
 protein coding gene Chr4:126445669-126447630 (+)
PWK/PhJ MGP_PWKPhJ_G0027620
 protein coding gene Chr4:119642470-119644432 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027446
 protein coding gene Chr4:122261759-122263732 (+)
WSB/EiJ MGP_WSBEiJ_G0027979
 protein coding gene Chr4:126537199-126539160 (+)



Homology
more
  • Human Ortholog
    LSM10, LSM10, U7 small nuclear RNA associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSM10, LSM10, U7 small nuclear RNA associated
  • Synonyms
    MST074, MSTP074
  • Links
    NCBI Gene ID: 84967
    neXtProt AC: NX_Q969L4
    UniProt: Q969L4

  • Chr Location
    1p34.3; chr1:36391238-36397908 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Lsm10
  • Find Mice (IMSR)
    16 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    50
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050188 Ensembl Gene Model | MGI Sequence Detail 1962 C57BL/6J ±  kb
transcript ENSMUST00000179323 Ensembl | MGI Sequence Detail 808 Not Applicable  
polypeptide ENSMUSP00000136585 Ensembl | MGI Sequence Detail 122 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:71849 Pillai RS, et al., Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. EMBO J. 2001 Oct 1;20(19):5470-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory