Tnfrsf21 MGI Mouse Gene Detail - MGI:2151075 - tumor necrosis factor receptor superfamily, member 21

Symbol

Tnfrsf21
Name

tumor necrosis factor receptor superfamily, member 21
Synonyms

Death receptor 6, DR6, TR7

Feature Type

protein coding gene
IDs

MGI:2151075
NCBI Gene: 94185
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr17:43327446-43400079 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.69 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

2458 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151075	protein coding gene	Chr17:43327446-43400080 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023771	protein coding gene	Chr17:43888584-43962324 (+)
A/J	MGP_AJ_G0023729	protein coding gene	Chr17:42899644-42972710 (+)
AKR/J	MGP_AKRJ_G0023700	protein coding gene	Chr17:43114688-43190051 (+)
BALB/cJ	MGP_BALBcJ_G0023733	protein coding gene	Chr17:42791880-42864774 (+)
C3H/HeJ	MGP_C3HHeJ_G0023497	protein coding gene	Chr17:43814791-43890722 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024176	protein coding gene	Chr17:45835952-45913660 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021626	protein coding gene	Chr17:39762282-39834784 (+)
CAST/EiJ	MGP_CASTEiJ_G0022978	protein coding gene	Chr17:43821648-43897481 (+)
CBA/J	MGP_CBAJ_G0023473	protein coding gene	Chr17:47471340-47550912 (+)
DBA/2J	MGP_DBA2J_G0023599	protein coding gene	Chr17:41712893-41784257 (+)
FVB/NJ	MGP_FVBNJ_G0023566	protein coding gene	Chr17:41268405-41343002 (+)
LP/J	MGP_LPJ_G0023680	protein coding gene	Chr17:44529065-44605719 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023595	protein coding gene	Chr17:47118193-47197261 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024221	protein coding gene	Chr17:43460839-43537023 (+)
PWK/PhJ	MGP_PWKPhJ_G0022723	protein coding gene	Chr17:40955069-41029210 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022538	protein coding gene	Chr17:40339913-40414316 (+)
WSB/EiJ	MGP_WSBEiJ_G0023043	protein coding gene	Chr17:43986261-44063208 (+)

Human Ortholog

TNFRSF21, TNF receptor superfamily member 21

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFRSF21, TNF receptor superfamily member 21
Synonyms

BM-018, CD358, DR6
Links

HGNC:13469

NCBI Gene ID: 27242

neXtProt AC: NX_O75509

UniProt: O75509
Chr Location

6p12.3; chr6:47231532-47309905 (-) GRCh38

MGI Vertebrate Homology

Tnfrsf21 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFRSF21
Gene Tree

Tnfrsf21

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Phenotype Summary

29 phenotypes from 4 alleles in 5 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

3
Gene trapped

7
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

971
Tissues

46
cDNA Data

80
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnfrsf21

ZFIN tnfrsf21

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS28794.1

Ensembl

ENSMUSG00000023915 (Evidence)
NCBI Gene

94185

			Length	Strain/Species	Flank
genomic	94185	NCBI Gene Model \| MGI Sequence Detail	72634	C57BL/6J	± kb
transcript	NM_178589	RefSeq \| MGI Sequence Detail	3626	C57BL/6
polypeptide	Q9EPU5	UniProt \| EBI \| MGI Sequence Detail	655	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016484 tumor necrosis factor receptor superfamily member 21

(term hierarchy)
PDB

4YN0
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR001368 TNFR/NGFR cysteine-rich region

IPR034037 Tumor necrosis factor receptor 21, death domain

IPR034034 Tumor necrosis factor receptor 21, N-terminal

IPR022330 Tumour necrosis factor receptor 21
GlyGen

Q9EPU5 7 sites, 3 N-linked glycans (3 sites)

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All nucleic 81

cDNA 81

Microarray probesets 4

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MGI:2146783, MGI:2147154

Summaries

All 59

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 23
Earliest

J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Tnfrsf21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144657	Chr17:43327400-43327409 (+)	-41 bp
Tssr144658	Chr17:43327413-43327426 (+)	-26 bp
Tssr144659	Chr17:43327427-43327482 (+)	9 bp
Tssr144660	Chr17:43338013-43338014 (+)	10,568 bp
Tssr144661	Chr17:43347239-43347273 (+)	19,810 bp
Tssr144662	Chr17:43348575-43348587 (+)	21,135 bp
Tssr144663	Chr17:43356808-43356824 (+)	29,370 bp
Tssr144664	Chr17:43388202-43388209 (+)	60,760 bp
Tssr144665	Chr17:43398653-43398664 (+)	71,213 bp
Tssr144666	Chr17:43398789-43398803 (+)	71,350 bp
Tssr144667	Chr17:43398880-43398893 (+)	71,441 bp
Tssr144668	Chr17:43398899-43398916 (+)	71,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24