Adarb2 MGI Mouse Gene Detail - MGI:2151118 - adenosine deaminase, RNA-specific, B2

Symbol

Adarb2
Name

adenosine deaminase, RNA-specific, B2
Synonyms

Adar3, RED2

Feature Type

protein coding gene
IDs

MGI:2151118
NCBI Gene: 94191
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:8252902-8818783 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 3.48 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

15608 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151118	protein coding gene	Chr13:8252475-8818798 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020217	protein coding gene	Chr13:4807253-5386487 (+)
A/J	MGP_AJ_G0020173	protein coding gene	Chr13:4823202-5382959 (+)
AKR/J	MGP_AKRJ_G0020148	protein coding gene	Chr13:4867152-5452463 (+)
BALB/cJ	MGP_BALBcJ_G0020156	protein coding gene	Chr13:4798714-5378415 (+)
C3H/HeJ	MGP_C3HHeJ_G0019960	protein coding gene	Chr13:4970170-5557816 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020603	protein coding gene	Chr13:5078063-5677376 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018212	protein coding gene	Chr13:4795780-5340522 (+)
CAST/EiJ	MGP_CASTEiJ_G0019500	protein coding gene	Chr13:4702456-5292528 (+)
CBA/J	MGP_CBAJ_G0019927	protein coding gene	Chr13:5216931-5855382 (+)
DBA/2J	MGP_DBA2J_G0020044	protein coding gene	Chr13:4667929-5224329 (+)
FVB/NJ	MGP_FVBNJ_G0020029	protein coding gene	Chr13:4529536-5081535 (+)
LP/J	MGP_LPJ_G0020118	protein coding gene	Chr13:4925086-5503052 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020065	protein coding gene	Chr13:5548382-6161151 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020631	protein coding gene	Chr13:4823203-5405616 (+)
PWK/PhJ	MGP_PWKPhJ_G0019261	protein coding gene	Chr13:4669184-5238132 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019068	protein coding gene	Chr13:4841359-5441869 (+)
WSB/EiJ	MGP_WSBEiJ_G0019558	protein coding gene	Chr13:4745798-5314446 (+)

Human Ortholog

ADARB2, adenosine deaminase RNA specific B2 (inactive)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADARB2, adenosine deaminase RNA specific B2 (inactive)
Synonyms

ADAR3, RED2
Links

HGNC:227

NCBI Gene ID: 105

neXtProt AC: NX_Q9NS39

UniProt: Q9NS39
Chr Location

10p15.3; chr10:1177313-1737525 (-) GRCh38

MGI Vertebrate Homology

Adarb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADARB2
Gene Tree

Adarb2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased anxiety-related behavior and impaired contextual learning and memory.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1085
Tissues

151
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adarb2

ZFIN adarb2

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All Sequences

54
RefSeq

8
UniProt

4
CCDS

CCDS26231.1, CCDS70428.1

Ensembl

ENSMUSG00000052551 (Evidence)
NCBI Gene

94191

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052551	Ensembl Gene Model \| MGI Sequence Detail	565882	C57BL/6J	± kb
transcript	ENSMUST00000064473	Ensembl \| MGI Sequence Detail	6721	Not Applicable
polypeptide	ENSMUSP00000064775	Ensembl \| MGI Sequence Detail	745	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003747 double-stranded RNA-specific editase B2

(term hierarchy)
EC

3.5.-.-
InterPro Domains

IPR044460 ADAR3, first double-stranded RNA binding domain

IPR002466 Adenosine deaminase/editase

IPR014720 Double-stranded RNA-binding domain

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All nucleic 21

cDNA 18

Primer pair 3

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 10
Earliest

J:62936 Slavov D, et al., Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish. Gene. 2000 May 30;250(1-2):41-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adarb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118292	Chr13:8252896-8252907 (+)	0 bp
Tssr118293	Chr13:8252921-8252954 (+)	36 bp
Tssr118294	Chr13:8252958-8252971 (+)	63 bp
Tssr118295	Chr13:8293780-8293783 (+)	40,880 bp
Tssr118297	Chr13:8343002-8343015 (+)	90,107 bp
Tssr118298	Chr13:8351531-8351536 (+)	98,632 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24