Bdt3 QTL Detail

Summary

• Symbol
  Bdt3
• Name
  bone density traits 3

• Feature Type
  QTL
• IDs
  MGI:2151121
  NCBI Gene: 116857
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, 63.63 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  116857

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:69682 Drake TA, et al., Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics. 2001 Apr 27;5(4):205-15
• Latest
  J:104825 Mehrabian M, et al., Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet. 2005 Nov;37(11):1224-33

Candidate Genes for Bdt3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Alox5	Chr6:116387038-116438139 (-)	J:104825	Previously identified QTL Bdt3 (bone density traits 3) at 67 cM on mouse Chromosome 6 is a pleiotropic locus associated with obesity, leptin levels, bone density, and VLDL/LDL levels. (C57BL/6J x DBA/2J)F2 animals homozygous for DBA/2J-derived alleles atBdt3 exhibit increased fat pad mass, plasma leptin, bone mineral density, and plasma VLDL/LDL cholesterol compared to F2 animals homozygous for C57BL/6J-derived alleles. F2 animals homozygous for DBA/2J-derived alleles at Alox5 (53.2 cM) also follow the same phenotypic pattern. In addition, B6.129S2-Alox5/J knockout animals also exhibit increased fat pads, plasma leptin and VLDL/LDL levels, and bone density compared to C57BL/6J. The Bdt3 interval contains 331 genes. Expression QTL analysis of (C57BL/6JxDBA/2J)F2 liver RNA identified Alox5 as a strong candidate gene. The DBA/2J Alox5 gene sequence has 66 SNPs compared to C57BL/6J, which include 1 missense mutation (resulting in reduced Alox5 enzymatic activity) and 2 SNPs in the 3' untranslated region. Authors speculate Alox5 is in part responsible for the pleiotropic effects of Bdt3.