Mta3 MGI Mouse Gene Detail - MGI:2151172

Symbol

Mta3
Name

metastasis associated 3
Synonyms

1110002J22Rik, mKIAA1266

Feature Type

protein coding gene
IDs

MGI:2151172
NCBI Gene: 116871
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr17:84013592-84128945 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 54.53 cM, cytoband E4
Mapping Data

3 experiments

SNPs within 2kb

3675 from dbSNP Build 142
Strain Annotations

30

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151172	protein coding gene	Chr17:84013483-84131144 (+)
129S1/SvImJ	ENSMUSG00200023397	protein coding gene	Chr17:79403536-79517671 (+)
129S1/SvImJ	ENSMUSG00200023450	protein coding gene	Chr17:79519425-79521013 (+)
A/J	ENSMUSG00195026926	protein coding gene	Chr17:80892823-80894411 (+)
A/J	ENSMUSG00195026847	protein coding gene	Chr17:80776940-80891069 (+)
AKR/J	ENSMUSG00220012902	protein coding gene	Chr17:79734424-79848586 (+)
AKR/J	ENSMUSG00220012931	protein coding gene	Chr17:79850340-79851928 (+)
BALB/cJ	ENSMUSG00180004828	protein coding gene	Chr17:80456941-80571208 (+)
BALB/cJ	ENSMUSG00180004856	protein coding gene	Chr17:80572962-80574550 (+)
C3H/HeJ	ENSMUSG00175014957	protein coding gene	Chr17:79831314-79832902 (+)
C3H/HeJ	ENSMUSG00175014899	protein coding gene	Chr17:79715420-79829560 (+)
C57BL/6NJ	ENSMUSG00215010721	protein coding gene	Chr17:79450419-79564693 (+)
C57BL/6NJ	ENSMUSG00215011024	protein coding gene	Chr17:79566447-79568035 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021919	protein coding gene	Chr17:79294634-79409952 (+)
CAST/EiJ	ENSTCUG00005015293	protein coding gene	Chr17:80252025-80365773 (+)
CBA/J	ENSMUSG00210020374	protein coding gene	Chr17:79574164-79688301 (+)
CBA/J	ENSMUSG00210020409	protein coding gene	Chr17:79690055-79691643 (+)
DBA/2J	ENSMUSG00185020072	protein coding gene	Chr17:82401740-82515463 (+)
FVB/NJ	ENSMUSG00205017666	protein coding gene	Chr17:80220283-80334542 (+)
FVB/NJ	ENSMUSG00205017968	protein coding gene	Chr17:80336296-80337884 (+)
JF1/MsJ	ENSUMUG00000009766	protein coding gene	Chr17:82135154-82248768 (+)
LP/J	ENSMUSG00230009198	protein coding gene	Chr17:83537955-83539543 (+)
LP/J	ENSMUSG00230009111	protein coding gene	Chr17:83422063-83536201 (+)
NOD/ShiLtJ	ENSMUSG00190009719	protein coding gene	Chr17:79603627-79605215 (+)
NOD/ShiLtJ	ENSMUSG00190009677	protein coding gene	Chr17:79487322-79601873 (+)
NZO/HlLtJ	ENSMUSG00225030239	protein coding gene	Chr17:85799022-85800610 (+)
NZO/HlLtJ	ENSMUSG00225030224	protein coding gene	Chr17:85682930-85797268 (+)
PWK/PhJ	ENSLUMG00010004861	protein coding gene	Chr17:79336423-79450763 (+)
SPRET/EiJ	ENSMSPG00010007746	protein coding gene	Chr17:79894938-80006962 (+)
WSB/EiJ	ENSIUOG00005009819	protein coding gene	Chr17:80403280-80517681 (+)

Human Ortholog

MTA3, metastasis associated 1 family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTA3, metastasis associated 1 family member 3
Links

HGNC:23784

NCBI Gene ID: 57504

UniProt: Q9BTC8
Chr Location

2p21; chr2:42494110-42756947 (+) GRCh38

MGI Vertebrate Homology

Mta3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTA3
Gene Tree

Mta3

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

255
Endonuclease-mediated

3
Gene trapped

243
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

122 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

77
cDNA Data

20
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MTA3

ZFIN mta3

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All Sequences

110
RefSeq

26
UniProt

14
CCDS

CCDS28997.1, CCDS50195.1, CCDS50196.1, CCDS50197.1

Ensembl

ENSMUSG00000055817 (Evidence)
NCBI Gene

116871

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055817	Ensembl Gene Model \| MGI Sequence Detail	115354	C57BL/6J	± kb
transcript	ENSMUST00000067826	Ensembl \| MGI Sequence Detail	2087	Not Applicable
polypeptide	ENSMUSP00000068931	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000010709 metastasis-associated protein MTA3

(term hierarchy)
PDB

2CRG
InterPro Domains

IPR001025 Bromo adjacent homology (BAH) domain

IPR043151 Bromo adjacent homology (BAH) domain superfamily

IPR000949 ELM2 domain

IPR009057 Homeodomain-like superfamily

IPR040138 Mesoderm induction early response protein/metastasis-associated protein

IPR035170 Metastasis-associated protein MTA1, R1 domain

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR000679 Zinc finger, GATA-type

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All nucleic 22

cDNA 20

Primer pair 2

Antibodies 1

Microarray probesets 6

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MGI:1915798

Summaries

All 70

Developmental Gene Expression 12

Gene Ontology 15

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:371045 Chrysovergis K, et al., A novel mutant allele of Mta3 in the mouse: genetic analysis of roles in immunity and androgen biology. G3 (Bethesda). 2025 Aug 4;

TSS for Mta3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145992	Chr17:84013320-84013342 (+)	-261 bp
Tssr145993	Chr17:84013566-84013598 (+)	-10 bp
Tssr145994	Chr17:84013599-84013629 (+)	22 bp
Tssr145995	Chr17:84013640-84013689 (+)	73 bp
Tssr145996	Chr17:84036570-84036580 (+)	22,983 bp
Tssr145997	Chr17:84036621-84036631 (+)	23,034 bp
Tssr145998	Chr17:84082914-84082921 (+)	69,326 bp
Tssr145999	Chr17:84082936-84082945 (+)	69,349 bp
Tssr146000	Chr17:84082951-84082968 (+)	69,368 bp
Tssr146001	Chr17:84082985-84083032 (+)	69,417 bp
Tssr146002	Chr17:84083057-84083066 (+)	69,470 bp
Tssr146003	Chr17:84083085-84083096 (+)	69,499 bp
Tssr146004	Chr17:84102793-84102812 (+)	89,211 bp
Tssr146005	Chr17:84102824-84102831 (+)	89,236 bp
Tssr146006	Chr17:84111722-84111746 (+)	98,142 bp
Tssr146007	Chr17:84118076-84118094 (+)	104,493 bp
Tssr146008	Chr17:84118189-84118204 (+)	104,605 bp
Tssr146009	Chr17:84118338-84118359 (+)	104,757 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24